Document Detail

Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
MedLine Citation:
PMID:  17562164     Owner:  NLM     Status:  MEDLINE    
Cell swelling is associated with the activation of an increase in the osmosensitive taurine release (OTR) rate, which serves to decrease cell volume as part of a process known as regulatory volume decrease. OTR, which is sensitive to many pharmacological agents including anion channel blockers and signalling pathway modulators, has also been suggested to play a role in cell cycle progression. At non-cytotoxic concentrations, the anion channel blocker NPPB (25 microM), the extra-cellular signal-regulated kinase inhibitor PD98059 (50 microM), and the c-Jun NH2-terminal kinase inhibitor SP 600125 (5 microM) each decreased the OTR rate by > or =50%, decreased cell proliferation, and increased G0/G1 cell cycle arrest.
Mark J Belsey; Andrew R L Davies; Harry J Witchel; Roland Z Kozlowski
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Publication Detail:
Type:  Journal Article     Date:  2007-06-12
Journal Detail:
Title:  Neurochemical research     Volume:  32     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-09-27     Completed Date:  2007-12-06     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1940-9     Citation Subset:  IM    
Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
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MeSH Terms
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / pharmacology
Anthracenes / pharmacology
Apoptosis / drug effects
Astrocytoma / metabolism*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Dicumarol / pharmacology
Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors*
Flavonoids / pharmacology*
Imidazoles / pharmacology
Ion Channels / antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors*
Necrosis / etiology
Niflumic Acid / pharmacology
Nitrobenzoates / pharmacology
Osmolar Concentration
Pyridines / pharmacology
Taurine / secretion*
Reg. No./Substance:
0/2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0/Anthracenes; 0/Flavonoids; 0/Imidazoles; 0/Ion Channels; 0/Nitrobenzoates; 0/Pyridines; 0/SB 203580; 0/anthra(1,9-cd)pyrazol-6(2H)-one; 107-35-7/Taurine; 3A35O9G3YZ/5-nitro-2-(3-phenylpropylamino)benzoic acid; 4394-00-7/Niflumic Acid; 53005-05-3/4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 66-76-2/Dicumarol; EC Signal-Regulated MAP Kinases; EC Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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