Document Detail

Inhibition of E rosetting and of OKT 11 in patients with oral dysplasia and neoplasia.
MedLine Citation:
PMID:  3292044     Owner:  NLM     Status:  MEDLINE    
A group of patients with oral dysplastic or early neoplastic lesions has been followed for 6 years to examine the change in ALS (antilymphocyte serum) induced 25% E rosette inhibition during the course of their disease. Control patients with other oral problems were examined similarly. The E rosette inhibition titer differences seen in our previous studies between control and diseased patients do not appear to persist with a longitudinal examination of these patients. While at early examination the patients exhibit higher inhibition titers than controls, later analysis shows that they seem to return to normal. To improve methodology, inhibition of OKT 11 uptake was substituted for E rosette inhibition and it is clear that both methods measure the same phenomenon. Thus, the former is more accurate and quantitative than the latter and will be used in future work. Continuation of these studies with the examination of more patients will be of value in assessing possible T lymphocyte changes in patients with oral lesions.
M F La Via; P F Rust; D R Weathers; B Norton-Koger; H W Peeler; S N Kreitzman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  11     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1988  
Date Detail:
Created Date:  1988-08-24     Completed Date:  1988-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
Department of Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
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MeSH Terms
Antigens, Surface / analysis,  immunology*
Fluorescent Antibody Technique
Lymphocytes / immunology*
Mouth Neoplasms / diagnosis,  immunology*
Precancerous Conditions / diagnosis,  immunology*
Reference Values
Rosette Formation
Tumor Markers, Biological
Reg. No./Substance:
0/Antigens, Surface; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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