| Inhibition of DNA synthesis and neoplastic cell growth by vitamin A (retinol). | |
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MedLine Citation:
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PMID: 3459909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inhibitory effect of vitamin A alcohol (retinol) on the DNA synthesis and neoplastic cell growth of chemically induced carcinomas (squamous cell carcinomas in Swiss male albino mice and basal cell carcinomas in inbred SD rats) by 3-methylcholanthrene [(MCA) CAS: 56-49-5] was studied. A marked inhibition of squamous cell carcinomas and basal cell carcinomas was observed following a combined administration of MCA and vitamin A (retinol) compared to the finding for animals treated with MCA alone (P less than .001). DNA radioactivity and autoradiographic studies with the use of [3H]thymidine showed a marked inhibition of DNA synthesis (twofold to threefold) in the neoplastic cell nuclei following a concomitant administration of vitamin A (retinol) and MCA (12%) as compared to the DNA synthesis following administration of MCA alone (31%) (P less than .001). Electron microscopic and cytologic observations revealed an advanced cytolysis and disorganization of neoplastic cells with reduction of polysomes, tonofilaments, and lysosome populations and mitochondrial alterations following vitamin A and MCA administration as compared to characteristic squamous neoplastic cells and basal neoplastic cells following MCA treatment alone. In addition, scanning electron microscopy revealed advanced changes of cell surfaces with reduction of microvilli and disorganization of cytoarchitecture. The present findings demonstrate that vitamin A exerts its anticarcinogenic effect by inhibiting DNA synthesis, disrupting cell surfaces, and possibly interfering with MCA metabolism in epidermal cells. |
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Authors:
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A Lupulescu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 77 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-08-18 Completed Date: 1986-08-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Autoradiography Carcinoma, Basal Cell / chemically induced, prevention & control*, ultrastructure Carcinoma, Squamous Cell / chemically induced, prevention & control*, ultrastructure Cell Division / drug effects DNA, Neoplasm / biosynthesis Male Methylcholanthrene / antagonists & inhibitors Mice Microscopy, Electron, Scanning Rats Rats, Inbred Strains Skin Neoplasms / chemically induced, prevention & control*, ultrastructure Vitamin A / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 11103-57-4/Vitamin A; 56-49-5/Methylcholanthrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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