Document Detail


Inhibition of DNA synthesis in mouse epidermis and breast epithelium by dehydroepiandrosterone and related steroids.
MedLine Citation:
PMID:  6456847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term treatment of C3H mice with the adrenal steroid, dehydroepiandrosterone (DHEA), has previously been shown to suppress spontaneous breast cancer development. A single i.p. injection of DHEA into C3H or ICR mice inhibits the rate of [3H]thymidine incorporation in breast epithelium and in 12-0-tetradecanoylphorbol-13-acetate (TPA)-stimulated epidermis. DHEA is a potent non-competitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). 16 alpha-Br-epiandrosterone (Br-Epi), which is 60 times more active than DHEA is an inhibitor of G6PDH, is also much more active in reducing the rate of [3H]thymidine incorporation into mouse breast epithelium and epidermis. Synthetically prepared DHEA-sulfatide also inhibits G6PDH activity and [3H]thymidine incorporation in TPA-stimulated mouse epidermis. On the contrary, DHEA-sulfate, which is virtually inactive as an inhibitor of G6PDH, is also inactive as an inhibitor of [3H]thymidine incorporation in mouse epidermis.
Authors:
L L Pashko; A G Schwartz; M Abou-Gharbia; D Swern
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  2     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1981  
Date Detail:
Created Date:  1981-12-15     Completed Date:  1981-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Breast / metabolism*
DNA / biosynthesis*
Dehydroepiandrosterone / analogs & derivatives*,  pharmacology*
Epidermis / metabolism*
Epithelium / metabolism
Glucosephosphate Dehydrogenase / metabolism
Male
Mice
Mice, Inbred C3H
Mice, Inbred ICR
Steroids / metabolism
Thymidine / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
AG-00368/AG/NIA NIH HHS; CA-14661/CA/NCI NIH HHS; CA501-273-01/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Steroids; 50-89-5/Thymidine; 53-43-0/Dehydroepiandrosterone; 9007-49-2/DNA; EC 1.1.1.49/Glucosephosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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