Document Detail

Inhibition of DNA restriction enzyme digestion by anthracyclines.
MedLine Citation:
PMID:  2836942     Owner:  NLM     Status:  MEDLINE    
The inhibition of restriction enzyme digestion of lambda phage DNA by anthracyclines (i.e., adriamycin, daunomycin, epirubicin, idarubicin and esorubicin) commonly used in the treatment of human leukemia and cancer has been studied in vitro. The anthracyclines used inhibit DNA digestion by SmaI, AvaII, HaeIII, HhaI and HpaII, which cut DNA at guanine-cytosine (G-C) sequence sites, and by EcoRI, which cut DNA at adenine adenine-thymine thymine (AATT) sequence sites. Adriamycin completely inhibits DNA restriction by the indicated enzymes, daunomycin, epirubicin and idarubicin determine only a partial inhibition, while esorubicin does not inhibit DNA restriction at all. An attempt is made to correlate the extent of the in vitro interaction between anthracyclines and DNA to in vivo cardiotoxicity.
G Corneo; E Pogliani; D Biassoni; P Tripputi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  La Ricerca in clinica e in laboratorio     Volume:  18     ISSN:  0390-5748     ISO Abbreviation:  Ric Clin Lab     Publication Date:    1988 Jan-Mar
Date Detail:
Created Date:  1988-07-11     Completed Date:  1988-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613947     Medline TA:  Ric Clin Lab     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  19-22     Citation Subset:  IM    
Cattedra di Patologia Medica II, Università degli Studi di Milano.
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MeSH Terms
Antibiotics, Antineoplastic
Bacteriophage lambda / drug effects,  metabolism
DNA Restriction Enzymes / antagonists & inhibitors*
DNA, Viral / metabolism
Naphthacenes / metabolism,  pharmacology
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/DNA, Viral; 0/Naphthacenes; EC 3.1.21.-/DNA Restriction Enzymes

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