Document Detail


Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.
MedLine Citation:
PMID:  20970123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions.
Authors:
Allison K Rodgers; Anitha Nair; Peter A Binkley; Rajeshwar Tekmal; Robert S Schenken
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-02-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas 78229, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylgalactosamine / analogs & derivatives*,  pharmacology,  therapeutic use
Antigens, CD44 / metabolism*
Benzyl Compounds / pharmacology*,  therapeutic use
Cell Adhesion / drug effects
Cell Line
Cell Survival / drug effects
Drug Evaluation, Preclinical
Endometriosis / pathology,  prevention & control
Endometrium / drug effects*,  metabolism,  physiology
Enzyme Inhibitors / pharmacology,  therapeutic use
Epithelial Cells / drug effects,  metabolism,  physiology
Epithelium / drug effects*,  metabolism,  physiology
Female
Glycosylation
Humans
Peritoneal Cavity / cytology
Peritoneal Diseases / pathology,  prevention & control
Protein Processing, Post-Translational / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
HD044135/HD/NICHD NIH HHS; HD049637/HD/NICHD NIH HHS; P30 CA54174/CA/NCI NIH HHS; R01 HD044135-03/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/Benzyl Compounds; 0/CD44 protein, human; 0/Enzyme Inhibitors; 31022-50-1/Acetylgalactosamine; 3554-93-6/benzyl-alpha-N-acetylgalactosamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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