| Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells. | |
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MedLine Citation:
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PMID: 20970123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions. |
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Authors:
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Allison K Rodgers; Anitha Nair; Peter A Binkley; Rajeshwar Tekmal; Robert S Schenken |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: 2011-02-28 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 823-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas 78229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylgalactosamine
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analogs & derivatives*,
pharmacology,
therapeutic use Antigens, CD44 / metabolism* Benzyl Compounds / pharmacology*, therapeutic use Cell Adhesion / drug effects Cell Line Cell Survival / drug effects Drug Evaluation, Preclinical Endometriosis / pathology, prevention & control Endometrium / drug effects*, metabolism, physiology Enzyme Inhibitors / pharmacology, therapeutic use Epithelial Cells / drug effects, metabolism, physiology Epithelium / drug effects*, metabolism, physiology Female Glycosylation Humans Peritoneal Cavity / cytology Peritoneal Diseases / pathology, prevention & control Protein Processing, Post-Translational / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HD044135/HD/NICHD NIH HHS; HD049637/HD/NICHD NIH HHS; P30 CA54174/CA/NCI NIH HHS; R01 HD044135-03/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD44; 0/Benzyl Compounds; 0/CD44 protein, human; 0/Enzyme Inhibitors; 31022-50-1/Acetylgalactosamine; 3554-93-6/benzyl-alpha-N-acetylgalactosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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