| Inhibition of Azoxymethane-induced Preneoplastic Lesions in the Rat Colon by a Cooked Stearic Acid Complexed High-amylose Cornstarch. | |
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MedLine Citation:
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PMID: 21780846 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We evaluated a novel stearic-acid-complexed-high-amylose-cornstarch (SAC) for the prevention of preneoplastic lesions in the colon of azoxymethane (AOM)-treated Fisher344 rats fed resistant starches at 50-55% of the diet for 8 weeks. Uncooked-SAC (r-SAC) diet was compared with raw-normal-cornstarch-diet (r-CS) or raw-high-amylose-cornstarch-diet (r-HA), and water-boiled-CS (w-CS) was compared with w-HA and w-SAC, respectively. w-SAC markedly reduced MDF numbers compared with w-HA or w-CS. r-HA significantly decreased ACF numbers compared with r-CS or r-SAC. Increased cecum weight and decreased cecum pH were observed in SAC or HA groups. The highest amounts of total or individual SCFAs in cecum, and butyrate or propionate in feces were observed in the AOM-treated w-SAC group. This study revealed the effectiveness of a novel resistant starch on inhibiting colonic preneoplastic lesions and the importance of high moisture cooking on the suppression of colon carcinogenesis by this resistant starch. |
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Authors:
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Yinsheng Zhao; Jovin Hasjim; Li Li; Jay-Lin Jane; Suzanne Hendrich; Diane F Birt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-25 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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