Document Detail


Inhibition of A9 and A10 dopamine cells by the cholecystokinin-B antagonist LY262691: mediation through feedback pathways from forebrain sites.
MedLine Citation:
PMID:  8259526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diphenylpyrazolidinone cholecystokinin-B (CCK-B) antagonist LY262691 has been shown to decrease the number of spontaneously active dopamine (DA) cells in the ventral tegmental area (A10) and substantia nigra (A9) of the anesthetized rat. In the present study, we examined the localization of the receptors mediating these effects of LY262691 on A9 and A10 DA cells. In one group of anesthetized rats, the effects of systemic administration of LY262691 on the number of spontaneously active A9 or A10 DA cells was determined using extracellular, single-unit recordings after radio frequency lesions were placed in the nucleus accumbens, caudate-putamen, or medial prefrontal cortex. Lesions of the caudate-putamen blocked the effects of systemically administered LY262691 on the number of spontaneously active A9, but not A10, DA cells. Conversely, lesions of the n. accumbens blocked the effects of systemically administered LY262691 on A10, but not A9, DA cells. Lesions of the medial prefrontal cortex blocked the effects of systemically administered LY262691 on both A9 and A10 DA cells. In a separate group of anesthetized rats, the number of spontaneously active A9 or A10 DA cells was determined after LY262691 was microinjected into the n. accumbens, caudate-putamen, or medial prefrontal cortex. Microinjection of LY262691 into the caudate-putamen led to a significant decrease in the number of spontaneously active A9, but not A10, DA cells. Conversely, microinjection of LY262691 into the n. accumbens or medial prefrontal cortex led to a significant decrease in the number of spontaneously active A10, but not A9, DA cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K Rasmussen; J J Howbert; M E Stockton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  15     ISSN:  0887-4476     ISO Abbreviation:  Synapse     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-103     Citation Subset:  IM    
Affiliation:
Lilly Research Laboratories, Eli Lilly & Co., Lilly Corporate Center, Indianapolis, Indiana 46285.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Cholecystokinin / administration & dosage,  antagonists & inhibitors*,  pharmacology
Corpus Striatum / anatomy & histology,  cytology,  drug effects
Dopamine / physiology*
Feedback / physiology
Male
Microinjections
Neural Pathways / cytology,  drug effects
Nucleus Accumbens / anatomy & histology,  cytology,  drug effects
Prefrontal Cortex / anatomy & histology,  cytology,  drug effects
Prosencephalon / cytology,  drug effects,  physiology*
Pyrazoles*
Radio Waves
Rats
Rats, Sprague-Dawley
Receptors, Dopamine / drug effects
Chemical
Reg. No./Substance:
0/Pyrazoles; 0/Receptors, Dopamine; 138932-35-1/1-(4-bromophenylaminocarbonyl)-4,5-diphenyl-3-pyrazolidinone; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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