Document Detail


Inhibition of 7,12-dimethylbenz[a]anthracene-induced lung tumorigenesis in A/J mice by food restriction is reversed by adrenalectomy.
MedLine Citation:
PMID:  8625440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effect of underfeeding. In the present experiment the effect of food restriction, with or without prior adrenalectomy, on 7,12-dimethylbenz[a]anthracene (DMBA)-induced lung tumor development in A/J mice was explored. Food restriction (27%), beginning 3 weeks after a single oral dose of 0.5 mg DMBA and continued for the duration of the experiment (14 weeks), significantly inhibited lung adenoma development, whereas adrenalectomy 2 weeks before initiating food restriction abolished the tumor inhibitory effect of underfeeding and also enhanced tumor development in the ad libitum fed mice. Plasma corticosterone levels were significantly elevated in food-restricted A/J mice, whereas plasma dehydroepiandrosterone (DHEA) levels showed no apparent change. These studies suggest that adrenal gland secretory products may play a general role in the tumor preventive effect of food restriction in laboratory mice.
Authors:
L L Pashko; A G Schwartz
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  17     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-06-24     Completed Date:  1996-06-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene*
Adrenalectomy*
Animals
Carcinogens*
Corticosterone / blood
Dehydroepiandrosterone / blood
Fasting*
Lung Neoplasms / blood,  chemically induced*,  prevention & control
Male
Mice
Mice, Inbred A
Neoplasms, Experimental / blood,  chemically induced,  prevention & control
Grant Support
ID/Acronym/Agency:
CA 12227/CA/NCI NIH HHS; CA 60471/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 50-22-6/Corticosterone; 53-43-0/Dehydroepiandrosterone; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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