Document Detail

Inhibition of 50-kHz ultrasonic vocalizations by dopamine receptor subtype-selective agonists and antagonists in adult rats.
MedLine Citation:
PMID:  23192317     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Adult rats emit ultrasonic calls at around 22 and 50 kHz, which are often elicited by aversive and rewarding stimuli, respectively. Dopamine (DA) plays a role in aspects of both reward and aversion.
OBJECTIVE: The purpose of this study is to investigate the effects of DA receptor subtype-selective agonists on 22- and 50-kHz call rates.
METHODS: Ultrasonic calls were recorded in adult male rats that were initially screened with amphetamine to eliminate low 50-kHz callers. The remaining subjects were tested after acute intraperitoneal or subcutaneous injection of the following DA receptor-selective agonists and antagonists: A68930 (D1-like agonist), quinpirole (D2-like agonist), PD 128907 (D3 agonist), PD 168077 (D4 agonist), SCH 39166 (D1-like antagonist), L-741,626 (D2 antagonist), NGB 2904 (D3 antagonist), and L-745,870 (D4 antagonist). The indirect DA/noradrenaline agonist amphetamine served as a positive control.
RESULTS: As expected, amphetamine strongly increased 50-kHz call rates. In contrast, D1-, D2-, and D3-selective DA receptor agonists, when given alone, inhibited calling; combinations of D1- and D2-like agonists also decreased call rate. Given alone, the D1-like and D3 antagonists significantly decreased call rate, with a similar trend for the D2 antagonist. Agonist-antagonist combinations also decreased calling. The D4 agonist and antagonist did not significantly affect 50-kHz call rates. Twenty-two-kilohertz calls occurred infrequently under all drug conditions.
CONCLUSION: Following systemic drug administration, tonic pharmacological activation of D1-like or D2-like DA receptors, either alone or in combination, does not appear sufficient to induce 50-kHz calls. Dopaminergic transmission through D1, D2, and D3 receptors appears necessary for spontaneous calling.
Tina Scardochio; Paul B S Clarke
Related Documents :
23212907 - Regulation of the g-protein regulatory-gαi signaling complex by nonreceptor guanine nu...
23937487 - Real-time characterization of cannabinoid receptor 1 (cb1 ) allosteric modulators revea...
11250707 - Tyrosine kinase signalling in breast cancer: erbb family receptor tyrosine kinases.
24728867 - Sazetidine-a activates and desensitizes native α7 nicotinic acetylcholine receptors.
24607627 - Monoamine oxidase a suppresses hepatocellular carcinoma metastasis by inhibiting the ad...
6961757 - Peripheral vasospasm during beta-receptor blockade - a comparison between metoprolol an...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-29
Journal Detail:
Title:  Psychopharmacology     Volume:  226     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-08-29     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  589-600     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphetamine / pharmacology
Dopamine / metabolism*
Dopamine Agonists / pharmacology
Dopamine Antagonists / pharmacology
Rats, Long-Evans
Receptors, Dopamine D1 / agonists,  antagonists & inhibitors,  metabolism*
Receptors, Dopamine D2 / agonists,  antagonists & inhibitors,  metabolism*
Receptors, Dopamine D3 / agonists,  antagonists & inhibitors,  metabolism*
Vocalization, Animal / drug effects
Reg. No./Substance:
0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; CK833KGX7E/Amphetamine; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impulsive action in the 5-choice serial reaction time test in 5-HT(2C) receptor null mutant mice.
Next Document:  A new method of fabricating robust freeform 3D ceramic scaffolds for bone tissue regeneration.