| Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water. | |
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MedLine Citation:
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PMID: 3486036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic p.o. feeding of small amounts of ellagic acid, a naturally occurring dietary plant phenol, to BALB/c mice in drinking water afforded significant protection against skin tumorigenesis induced by 3-methylcholanthrene, a polycyclic aromatic hydrocarbon carcinogen. A significant increase in the latent period for the development of skin tumors by 3-methylcholanthrene was observed in the ellagic acid-fed group of mice (9 wk on test) as compared to the control group of animals (6 wk on test). The observed protection against tumor induction in the ellagic acid-fed group of animals may be due to the inhibition of the metabolic activation of the polycyclic aromatic hydrocarbon since epidermal aryl hydrocarbon hydroxylase activity was found to be significantly inhibited. Our results suggest that dietary supplementation with small amounts of ellagic acid may prove useful in reducing the risk of skin carcinogenesis induced by environmental chemicals. |
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Authors:
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H Mukhtar; M Das; D R Bickers |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 46 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-05-23 Completed Date: 1986-05-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2262-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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7-Alkoxycoumarin O-Dealkylase Administration, Oral Animals Aryl Hydrocarbon Hydroxylases / metabolism Benzopyrans / pharmacology* Ellagic Acid / administration & dosage, pharmacology* Epoxide Hydrolases / metabolism Glutathione Transferase / metabolism Male Methylcholanthrene / antagonists & inhibitors* Mice Mixed Function Oxygenases / metabolism Oxygenases / metabolism Skin / enzymology Skin Neoplasms / chemically induced* |
| Grant Support | |
ID/Acronym/Agency:
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AM 34368/AM/NIADDK NIH HHS; CA 38028/CA/NCI NIH HHS; ES 1900/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrans; 476-66-4/Ellagic Acid; 56-49-5/Methylcholanthrene; EC 1.-/Mixed Function Oxygenases; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 2.5.1.18/Glutathione Transferase; EC 3.3.2.-/Epoxide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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