Document Detail


Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water.
MedLine Citation:
PMID:  3486036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic p.o. feeding of small amounts of ellagic acid, a naturally occurring dietary plant phenol, to BALB/c mice in drinking water afforded significant protection against skin tumorigenesis induced by 3-methylcholanthrene, a polycyclic aromatic hydrocarbon carcinogen. A significant increase in the latent period for the development of skin tumors by 3-methylcholanthrene was observed in the ellagic acid-fed group of mice (9 wk on test) as compared to the control group of animals (6 wk on test). The observed protection against tumor induction in the ellagic acid-fed group of animals may be due to the inhibition of the metabolic activation of the polycyclic aromatic hydrocarbon since epidermal aryl hydrocarbon hydroxylase activity was found to be significantly inhibited. Our results suggest that dietary supplementation with small amounts of ellagic acid may prove useful in reducing the risk of skin carcinogenesis induced by environmental chemicals.
Authors:
H Mukhtar; M Das; D R Bickers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  46     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-05-23     Completed Date:  1986-05-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2262-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
7-Alkoxycoumarin O-Dealkylase
Administration, Oral
Animals
Aryl Hydrocarbon Hydroxylases / metabolism
Benzopyrans / pharmacology*
Ellagic Acid / administration & dosage,  pharmacology*
Epoxide Hydrolases / metabolism
Glutathione Transferase / metabolism
Male
Methylcholanthrene / antagonists & inhibitors*
Mice
Mixed Function Oxygenases / metabolism
Oxygenases / metabolism
Skin / enzymology
Skin Neoplasms / chemically induced*
Grant Support
ID/Acronym/Agency:
AM 34368/AM/NIADDK NIH HHS; CA 38028/CA/NCI NIH HHS; ES 1900/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Benzopyrans; 476-66-4/Ellagic Acid; 56-49-5/Methylcholanthrene; EC 1.-/Mixed Function Oxygenases; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 2.5.1.18/Glutathione Transferase; EC 3.3.2.-/Epoxide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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