Document Detail

Inhibition of 3 beta-hydroxysteroid dehydrogenase in the sow near term: effects on fetal and maternal steroids and on delivery.
MedLine Citation:
PMID:  3162325     Owner:  NLM     Status:  MEDLINE    
The effect of Epostane, a 3 beta-hydroxysteroid dehydrogenase inhibitor, on maternal and fetal plasma progesterone and other steroids has been investigated in chronically catheterized pregnant sows near term. Epostane (1-2 mg/kg) was given i.v. and samples withdrawn from the uterine vein and artery and a fetal artery. In seven sows tested at 106-110 d gestation (term 115 d) Epostane induced parturition 25 +/- 2.1 h later with the birth of live viable young (group 1). In four sows tested with the same dose of Epostane at 106-111 d gestation parturition was not induced (group 2). A rapid drop in maternal and fetal plasma progesterone occurred after Epostane; in group 1 maternal progesterone remained below 4 ng/ml until delivery whereas in group 2 the drop was temporary, as was the decrease in fetal progesterone in all animals. Epostane also resulted in a rapid fall in maternal and fetal plasma cortisol with a gradual recovery over the following 9-12 h which was accompanied by increased ACTH (adrenocorticotrophic hormone) levels in the fetus. In group 1 fetuses a further escalation in both cortisol and ACTH occurred up to and during delivery while in group 2 basal concentrations were restored after 24 h. Epostane also reduced maternal oestrone concentrations in both groups over the 6-9 h after drug treatment. In group 2 the basal oestrone concentrations and the oestrone/progesterone ratio before and after Epostane administration were lower than in group 1 which may in part explain the failure of Epostane to induce labour in the former despite their similar gestational age. It is concluded that Epostane is not a reliable inducing agent in the sow when infused within 5-10 d of term although enhanced adrenocortical activity probably ensures the viability of the piglets if delivered.
M Silver; A L Fowden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  73     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  67-78     Citation Subset:  IM    
Physiological Laboratory, Cambridge.
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MeSH Terms
3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
Androstenols / pharmacology*
Estrone / blood*
Fetal Blood / analysis
Hydrocortisone / blood*
Labor, Induced*
Labor, Obstetric
Pregnancy, Animal / metabolism*
Progesterone / blood*
Reference Values
Reg. No./Substance:
0/Androstenols; 50-23-7/Hydrocortisone; 53-16-7/Estrone; 57-83-0/Progesterone; 80471-63-2/epostane; EC 1.1.-/3-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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