Document Detail


Inhibition of 1,2-dimethylhydrazine-induced nuclear damage in rat colonic epithelium by chlorophyllin.
MedLine Citation:
PMID:  2817825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chlorophyllin (CHL) was tested for its effect on 1,2-dimethylhydrazine (DMH)-induced nuclear aberrations in rat colonic epithelium. Rats were given water containing CHL (1.5 mM) and food ad libitum. After 5 wks on this dietary regimen, the rats were given a single intraperitoneal injection of DMH (20 mg DMH base/kg body weight). The rats were sacrificed 18 hours later and their colons were removed. Ten consecutive crypts from the proximal and distal portion of each specimen were scored for nuclear aberrations and the karyorrhectic index (KI) was determined. Rats receiving CHL + DMH had significantly fewer nuclear aberrations (lower KI) in the colonic epithelium than rats given DMH alone. This implies that CHL, a known antimutagen, may have anticarcinogenic properties as well.
Authors:
E W Robins; R L Nelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  9     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-12-08     Completed Date:  1989-12-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  981-5     Citation Subset:  IM    
Affiliation:
University of Illinois College of Medicine, Department of Surgery, Chicago 60612.
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MeSH Terms
Descriptor/Qualifier:
1,2-Dimethylhydrazine
Animals
Body Weight / drug effects
Carcinogens / toxicity*
Cell Nucleus / drug effects,  ultrastructure*
Chlorophyll / analogs & derivatives*
Chlorophyllides / pharmacology*
Colon / drug effects,  pathology*
Dimethylhydrazines / toxicity*
Epithelium / drug effects,  pathology
Male
Methylhydrazines / toxicity*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Chlorophyllides; 0/Dimethylhydrazines; 0/Methylhydrazines; 1406-65-1/Chlorophyll; 15611-43-5/chlorophyllin; 540-73-8/1,2-Dimethylhydrazine

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