Document Detail

Inhibiting effect of dexamethasone on evolving myocardial necrosis in coronary-ligated rats, with and without reperfusion.
MedLine Citation:
PMID:  4080817     Owner:  NLM     Status:  MEDLINE    
Previous findings suggested that glucocorticosteroids may be able to preserve ischemic myocardial tissue from cellular necrosis. In the present investigation, the left coronary artery in rats was ligated either permanently, or reperfusion was allowed after an occlusion time of 40 min. After 5 h of permanent coronary ligation, or after 60 min of reperfusion, respectively, the hearts were investigated as to the extent of their ischemic and necrotic areas. The ischemic areas were determined by 'negative staining' with Evans blue, and the necrotic areas by 'negative staining' with triphenyltetrazolium chloride. Dexamethasone orthophosphate in both kinds of experiments significantly decreased the percentage of the ischemic area which had undergone necrosis.
W Bernauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology     Volume:  31     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1985  
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  328-36     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / pathology*
Dexamethasone / pharmacology*
Evans Blue / diagnostic use
Myocardium / pathology*
Necrosis / prevention & control
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
314-13-6/Evans Blue; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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