Document Detail


Inhibiting carbonic anhydrase in brain tissue increases the respiratory response to rebreathing CO2.
MedLine Citation:
PMID:  2118820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the respiratory effects of inhibiting carbonic anhydrase in brain tissue, we infused acetazolamide (ACZ) into the cisterna magna in anesthetized rats. Three concentrations, 4.5, 45 and 450 microM in artificial cerebrospinal fluid, were infused continuously at 2 microliter/min for 20 min and the responses to CO2 rebreathing trials were compared to sham CSF infusions without ACZ. Baseline, steady-state respiration during room air breathing was not affected by these doses of ACZ, but the two higher doses increased the minute ventilation rebreathing response. We conclude that inhibition of carbonic anhydrase in brain tissue increases the respiratory response to rebreathing CO2.
Authors:
J M Adams; N L Johnson
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  519     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-10-16     Completed Date:  1990-10-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, University of Virginia, Charlottesville 22908.
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MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology*
Animals
Brain / drug effects,  enzymology,  physiology*
Carbon Dioxide / blood
Carbonic Anhydrase Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Partial Pressure
Rats
Rats, Inbred Strains
Reference Values
Respiration / drug effects*
Time Factors
Grant Support
ID/Acronym/Agency:
GM 07593/GM/NIGMS NIH HHS; HL 01196/HL/NHLBI NIH HHS; HL 29396/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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