Document Detail

Inhibiting the Protein Ubiquitination Cascade by Ubiquitin-Mimicking Short Peptides.
MedLine Citation:
PMID:  23134251     Owner:  NLM     Status:  Publisher    
Short heptapeptides were identified to function as ubiquitin (UB) mimics that are activated by E1 and form thioester conjugates with E1, E2, and HECT type E3 enzymes. The activities (k(cat)/K(1/2)) of E1 with the UB-mimicking peptides are 130-1,400-fold higher than the equally long peptide with the native C-terminal sequence of UB. By forming covalent conjugates with E1, E2, and E3 enzymes, the UB-mimicking peptides can block the transfer of native UB through the cascade.
Bo Zhao; Chan Hee J Choi; Karan Bhuripanyo; Eric B Villhauer; Keya Zhang; Hermann Schindelin; Jun Yin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, University of Chicago , Chicago, Illinois 60637, United States, and Rudolf Virchow Center for Experimental Biomedicine and Institute for Structural Biology, University of Würzburg , Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
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