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Inhibiting the Protein Ubiquitination Cascade by Ubiquitin-Mimicking Short Peptides.
MedLine Citation:
PMID:  23134251     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Short heptapeptides were identified to function as ubiquitin (UB) mimics that are activated by E1 and form thioester conjugates with E1, E2, and HECT type E3 enzymes. The activities (k(cat)/K(1/2)) of E1 with the UB-mimicking peptides are 130-1,400-fold higher than the equally long peptide with the native C-terminal sequence of UB. By forming covalent conjugates with E1, E2, and E3 enzymes, the UB-mimicking peptides can block the transfer of native UB through the cascade.
Authors:
Bo Zhao; Chan Hee J Choi; Karan Bhuripanyo; Eric B Villhauer; Keya Zhang; Hermann Schindelin; Jun Yin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Chicago , Chicago, Illinois 60637, United States, and Rudolf Virchow Center for Experimental Biomedicine and Institute for Structural Biology, University of Würzburg , Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
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