Document Detail

Inhibited response to isoproterenol and altered action potential of beating rat heart cells by human serum in septic shock.
MedLine Citation:
PMID:  647872     Owner:  NLM     Status:  MEDLINE    
Human serum, obtained within 24 hours after the onset of septic shock, was evaluated for its effects on the chronotropic response of cultured rat myocardial cells to isoproterenol. Transmembrane action potential (AP) was measured in some experiments. Sera obtained after the first four to five hours, when central venous pressure (CVP) was normal or high, inhibited increased cell beats, while this property was not evidenced for samples taken soon after septic shock when CVP was low. Sera were also found to alter AP in much the same way as Sotalol, an adrenergic beta-blocking drug. These two effects were never observed with control sera obtained from healthy male adults at rest. These findings demonstrate that sera from patients in septic shock depress the beta-adrenergic response of rat myocardial cells, after the early phase of septic shock characterized by sympathoadrenergic activity. They strongly suggest the mediation of unidentified humoral factors, which might interfere in the pathogenesis of myocardial dysfunction during the intermediate phase of septic shock.
A Carli; M C Auclair; G Bleichner; S Weber; P Lechat; J F Monsallier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  5     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1978  
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-94     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Cells, Cultured
Heart / drug effects*
Isoproterenol / antagonists & inhibitors*
Receptors, Adrenergic / physiology
Shock, Septic / blood*
Stimulation, Chemical
Reg. No./Substance:
0/Receptors, Adrenergic; 7683-59-2/Isoproterenol

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