Document Detail

Inhibins as diagnostic markers in human reproduction.
MedLine Citation:
PMID:  18429491     Owner:  NLM     Status:  MEDLINE    
Over the past 75 years, many publications have focused on measurement of inhibin concentration and/or activity in biological samples in order to understand its role in physiology and disease. This chapter highlights the accomplishments within this area of research over the past decade including development of specific inhibin assays. Inhibin A is a marker of dominant follicle and corpus luteum activity and decreases in polycystic ovary syndrome (PCOS). Inhibin A increases in gestational diseases such as pre-eclampsia and fetal Down's syndrome, and this increase in inhibin A improves early diagnosis of both conditions. The measurement of inhibin A in women with threatened abortion provides useful information about the likelihood of pregnancy loss. Inhibin B increases markedly in women with granulosa cell tumor and appears closely related to gametogenesis in men, that is, reflecting Sertoli cell activity. On the contrary, Inhibin B decreases in women with declining ovarian function and correlates with female response to ovulation induction. This review evaluates the biochemical significance ofinhibins including their use in clinical practice.
Anastasia Tsigkou; Stefano Luisi; Fernando M Reis; Felice Petraglia
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in clinical chemistry     Volume:  45     ISSN:  0065-2423     ISO Abbreviation:  Adv Clin Chem     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-23     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985173R     Medline TA:  Adv Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-29     Citation Subset:  IM    
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico, S. Maria alle Scotte Viale Bracci, 53100 Siena, Italy.
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MeSH Terms
Infertility, Female / blood
Inhibins / blood*
Ovulation Induction
Pregnancy Complications / blood
Reg. No./Substance:

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