| Inhibin A and pro-alpha C inhibin in Down syndrome and normal pregnancies. | |
| | |
MedLine Citation:
|
PMID: 9854718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using two enzyme-linked immunosorbent assays specific for inhibin A and pro-alpha C inhibin, levels of the two proteins were assessed in maternal serum from 43 Down syndrome and 300 chromosomally normal pregnancies at 15-17 weeks' gestation. Compared to the control pregnancies, both inhibin A and pro-alpha C inhibin were significantly elevated in the Down syndrome pregnancies with median levels, expressed as multiples of the normal median, of 1.53 MoM and 1.34 MoM, respectively (P < 0.001 and P = 0.046 compared to controls). Levels of inhibin A and pro-alpha C inhibin were weakly but significantly correlated in both the control and the Down syndrome sera (r = 0.25, P < 0.0001; r = 0.4, P = 0.008, respectively). These data suggest that the mechanism(s) underlying the elevated inhibin levels observed in Down syndrome may affect the regulation of both the inhibin alpha- and beta A-subunits. |
| | |
Authors:
|
D D'Antona; E M Wallace; C Shearing; J P Ashby; N P Groome |
Related Documents
:
|
9074248 - Removal of adnexal masses by operative laparoscopy during pregnancy 18609068 - Haemoglobin, c-reactive protein and androgen levels in uncomplicated and complicated pr... 6409458 - Serum free thyroxine concentration and free thyroid hormone indices in normal pregnancy. 6126448 - Pregnancy specific proteins: suppression of in vitro blastogenic response to mitogen by... 21492048 - Description and genetic analysis of three sets of monozygotic twins resulting from tran... 8780938 - Three siblings with walker-warburg syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Prenatal diagnosis Volume: 18 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1998 Nov |
Date Detail:
|
Created Date: 1999-03-05 Completed Date: 1999-03-05 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1122-6 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Down Syndrome
/
blood* Female Gestational Age Humans Inhibins / blood* Peptides / blood* Pregnancy Protein Precursors / blood* Reference Values |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 0/Protein Precursors; 0/inhibin-alpha subunit; 0/inhibin-alpha subunit precursor; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: First report of prenatal biochemical diagnosis of Lowe syndrome.
Next Document: Effect of maternal age curve on the predicted detection rate in maternal serum screening for Down sy...