Document Detail


Inhibin A and pro-alpha C inhibin in Down syndrome and normal pregnancies.
MedLine Citation:
PMID:  9854718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using two enzyme-linked immunosorbent assays specific for inhibin A and pro-alpha C inhibin, levels of the two proteins were assessed in maternal serum from 43 Down syndrome and 300 chromosomally normal pregnancies at 15-17 weeks' gestation. Compared to the control pregnancies, both inhibin A and pro-alpha C inhibin were significantly elevated in the Down syndrome pregnancies with median levels, expressed as multiples of the normal median, of 1.53 MoM and 1.34 MoM, respectively (P < 0.001 and P = 0.046 compared to controls). Levels of inhibin A and pro-alpha C inhibin were weakly but significantly correlated in both the control and the Down syndrome sera (r = 0.25, P < 0.0001; r = 0.4, P = 0.008, respectively). These data suggest that the mechanism(s) underlying the elevated inhibin levels observed in Down syndrome may affect the regulation of both the inhibin alpha- and beta A-subunits.
Authors:
D D'Antona; E M Wallace; C Shearing; J P Ashby; N P Groome
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  18     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-03-05     Completed Date:  1999-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1122-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, Australia.
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MeSH Terms
Descriptor/Qualifier:
Down Syndrome / blood*
Female
Gestational Age
Humans
Inhibins / blood*
Peptides / blood*
Pregnancy
Protein Precursors / blood*
Reference Values
Chemical
Reg. No./Substance:
0/Peptides; 0/Protein Precursors; 0/inhibin-alpha subunit; 0/inhibin-alpha subunit precursor; 57285-09-3/Inhibins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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