| Inhibin A is a maternal serum marker for Down's syndrome early in the first trimester. | |
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MedLine Citation:
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PMID: 15952984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhibin A is a maternal serum marker for fetal Down's syndrome (DS) in the second trimester. We examined whether inhibin A could be used early in the first trimester. Maternal serum concentrations of inhibin A were determined in 81 controls and 27 cases of fetal trisomy 21 in gestational week 5-11. The log MoM (Multiple of the Median of normal pregnancies) inhibin A concentration in DS pregnancies increased with gestational age (p = 0.001) from a mean log MoM (standard deviation) of -0.1754 (0.3712) (n = 11) in week 7-8 to a mean log MoM (standard deviation) of 0.1842 (0.2145) (n = 12) in week 9-11. This corresponded to an increase in inhibin median MoM from 0.67 to 1.53. When inhibin A was used together with pregnancy-associated plasma protein-A, free beta-human chorionic gonadotrophin and nuchal translucency as DS markers, the estimated detection rates were 81.4 and 82.6% in weeks 7-8 and 9-11, respectively, for false-positive rates of 0.9 and 1.0%. The performance of the latter combination early in the first trimester is nearly as good as that of integrated first- and second-trimester screening, with the further advantage that the risk can be reported to the pregnant woman in first trimester. |
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Authors:
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M Christiansen; B Nørgaard-Pedersen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical genetics Volume: 68 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-14 Completed Date: 2005-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: Denmark |
Other Details:
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Languages: eng Pagination: 35-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark. mic@ssi.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Chorionic Gonadotropin, beta Subunit, Human / blood Down Syndrome / diagnosis* False Positive Reactions Female Humans Inhibins / blood* Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis Prenatal Diagnosis / methods* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/inhibin A; 57285-09-3/Inhibins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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