Document Detail

Inhibin A: marker for diagnosis of ectopic and early abnormal pregnancies.
MedLine Citation:
PMID:  19079962     Owner:  NLM     Status:  MEDLINE    
A prospective case-control study was performed to determine whether inhibin A concentration is a clinically useful marker of ectopic pregnancy (EP). Inhibin A concentration in patients diagnosed with EP by laparoscopic and pathological findings (n = 17) was compared with that in missed miscarriage (n = 35), incomplete miscarriage (n = 14), spontaneous miscarriage (n = 5), threatened miscarriage (n = 6), normal pregnancy (n = 24) and non-pregnant controls (n = 20). The data were analysed using the Mann-Whitney U-test. EP yielded significantly lower inhibin A concentrations compared with normal pregnancy, 12.7 +/- 11.7 versus 237.3 +/- 125.9 pg/ml (P < 0.0002), and similar concentrations to non-pregnant controls (13.3 +/- 14.3 pg/ml). Inhibin A concentrations in abnormal pregnancies were significantly lower than in the normal pregnancy group: missed miscarriage 42.4 +/- 54.9 pg/ml (P < 0.0002); spontaneous miscarriage 47.5 +/- 55.6 pg/ml (P < 0.0002); and incomplete miscarriage 12.2 +/- 10.5 pg/ml (P < 0.0002). Threatened miscarriage was not statistically different to normal pregnancy (183.1 +/- 119.4 pg/ml). Human chorionic gonadotrophin concentrations in EP were not statistically significantly different compared with missed miscarriage and incomplete miscarriage. In conclusion, serum inhibin A concentration may be a reliable marker of EP.
Shimon Segal; Hetal Gor; Nereida Correa; Ray Mercado; Korina Veenstra; Benjamin Rivnay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  17     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-04-24     Revised Date:  2009-06-01    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-94     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Lincoln Medical Center, Weill Medical, College of Cornell University, 234-149th Street, Bronx, NY 10451, USA.
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MeSH Terms
Abortion, Spontaneous / blood,  diagnosis
Case-Control Studies
Cohort Studies
Genetic Markers
Inhibins / biosynthesis*
Models, Statistical
Pregnancy / blood*
Pregnancy Complications / blood,  diagnosis
Pregnancy, Ectopic / blood*,  diagnosis*
Prospective Studies
Time Factors
Reg. No./Substance:
0/Genetic Markers; 0/inhibin A; 57285-09-3/Inhibins

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