Document Detail

Inherited thrombophilia: treatment during pregnancy.
MedLine Citation:
PMID:  16601339     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Inherited thrombophilia is associated with thromboembolic events and/or poor obstetric outcome. We evaluated the pregnancy outcome in women with inherited thrombophilia treated with low-molecular-weight heparin (LMWH). METHODS: 38 thrombophilic women with a history of thromboembolic events and/or poor obstetric outcome were treated during their 39 consecutive pregnancies with LMWH from pregnancy verification until 4-6 weeks in puerperium. A fixed dose of enoxaparin 4,000 IU/day (except 1 case who required nadroparin 0.3 ml/day) was administered in most cases, adopting a higher dose (6,000 IU/day to 6,000 IU twice a day) in those with previous thromboembolic events. RESULTS: In the treated women, all had a good obstetric outcome, whereas in the previous untreated pregnancies (n = 78), the rate of fetal loss (early and late) was 76.9%, only 12 live infants survived (66.6%). Moreover, birth weight resulted significantly higher in live infants born to treated pregnancies in comparison to that of previous untreated pregnancies (p = 0.009). No maternal thrombosis or major bleeding complications were recorded. CONCLUSIONS: The treatment with LMWH improved pregnancy outcome resulting effective and safe in thrombophilic women with a history of thromboembolic events and/or poor obstetric outcome.
Sara De Carolis; Sergio Ferrazzani; Valerio De Stefano; Serafina Garofalo; Gabriella Fatigante; Elena Rossi; Giuseppe Leone; Alessandro Caruso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  21     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Catholic University, Rome, Italy.
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MeSH Terms
Anticoagulants / administration & dosage,  adverse effects,  therapeutic use*
Birth Weight
Cesarean Section
Delivery, Obstetric / methods
Enoxaparin / administration & dosage,  therapeutic use
Fetal Death / epidemiology
Gestational Age
Pregnancy Complications, Hematologic / drug therapy*
Pregnancy Outcome
Thromboembolism / prevention & control
Thrombophilia / drug therapy*,  genetics*
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin

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