Document Detail

Inherited thrombophilia and pregnancy complications revisited.
MedLine Citation:
PMID:  18669729     Owner:  NLM     Status:  MEDLINE    
Inherited thrombophilias are not yet established as a cause of placenta-mediated pregnancy complications, such as fetal growth restriction, preeclampsia, abruption, and pregnancy loss. An inherited thrombophilia is only one of many factors that lead to development of these diseases and is unlikely to be the unique factor that should drive management in subsequent pregnancies. The paucity of evidence for benefit, coupled with a small potential for harm, suggests that low molecular weight heparin should be considered an experimental drug for these indications until data from controlled trials are published. At present, women with a history of placenta-mediated pregnancy complications, with or without a thrombophilia, should be followed closely without routine prophylactic low molecular weight heparin other than for prevention of venous thromboembolism in limited circumstances.
Marc A Rodger; Michael Paidas; Claire McLintock; McLintock Claire; Saskia Middeldorp; Susan Kahn; Ida Martinelli; William Hague; Karen Rosene Montella; Ian Greer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  112     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-4     Citation Subset:  AIM; IM    
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
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MeSH Terms
Abortion, Habitual / physiopathology
Heparin / therapeutic use
Heparin, Low-Molecular-Weight / therapeutic use
Placenta / physiopathology*
Placental Circulation / physiology*
Pregnancy Complications, Hematologic / physiopathology*
Thrombophilia / physiopathology*
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight; 9005-49-6/Heparin
Erratum In:
Obstet Gynecol. 2008 Dec;112(6):1392
Note: Claire, McLintock [corrected to McLintock, Claire]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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