Document Detail


Inherited tertiary hypothyroidism in Sprague-Dawley rats.
MedLine Citation:
PMID:  17368429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid hormones (THs) are important in the development and maturation of the central nervous system (CNS). The significant actions of THs during CNS development occur at the time when TH levels are lower than those in the mother and the hypothalamic-thyroid (HPT) axis is not fully functional. In the developing rat nervous system, primarily the cerebellum, the first three postnatal weeks represent a period of significant sensitivity to thyroid hormones. This study presents a spontaneous, inherited recessive hypothyroidism in Sprague-Dawley rats with devastating functional consequences to the development of the CNS. The clinical signs develop around 14 day's postnatal (dpn) and are characterized by ataxia, spasticity, weight loss and hypercholesterolemia. The afflicted rats died at 30 days due to severe neurological deficits. The deterioration affects the entire CNS and is characterized by progressive neuronal morphological and biochemical changes, demyelination and astrogliosis. The cerebellum, brain stem, neocortex, hippocampus and adrenal gland medulla appear to be most affected. Thyroid Stimulating Hormone (TSH), T3 and T4 levels were significantly lower in hypothyroid rats than control. Immunohistochemistry and RT-PCR demonstrated a reduction of Thyrotropin Releasing Hormone (TRH) in the hypothalamus of hypothyroid rats. The weight of both thyroid and pituitary glands were significantly less in hypothyroid rats than the corresponding normal littermate controls. Transmission electron microscopy demonstrates consistent postsynaptic dendritic, synaptic and spine alterative changes in the brain of hypothyroid rats. These data suggest that we discovered a tertiary form of inherited hypothyroidism involving the hypothalamus.
Authors:
George Stoica; Gina Lungu; Xueyi Xie; Louise C Abbott; Heidi M Stoica; John T Jaques
Related Documents :
19733399 - Inhibitory effect of aluminium on calcium absorption in small intestine of rats with di...
6545929 - The metabolism of 4-iodantipyrine--i125 (riap) in rat organism after intravenous inject...
11790339 - A thyrotropin-like molecule from the pituitary of an indian freshwater murrel: comparis...
3444849 - Hemodynamic parameters and renal blood flow following stimulation of renal tubular tran...
3700969 - Early inhibition and changes in diurnal rhythmicity of the pituitary-thyroid axis after...
9096849 - Effect of increased bromide intake on iodine excretion in rats.
15526359 - Peroxisome proliferator-activated receptor gamma ligands suppress liver carcinogenesis ...
6469209 - Regulation of phosphatidylcholine biosynthesis by the methylation pathway in rat pituit...
17461479 - Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohe...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-02-27
Journal Detail:
Title:  Brain research     Volume:  1148     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-07-25     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  205-16     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA. gstoica@cvm.tamu.edu <gstoica@cvm.tamu.edu>
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / abnormalities,  metabolism,  physiopathology
Animals
Brain / abnormalities*,  metabolism,  physiopathology
Congenital Hypothyroidism / complications*,  metabolism,  physiopathology
Female
Hypothalamus / metabolism,  physiopathology*,  secretion
Male
Microscopy, Electron, Transmission
Nerve Degeneration / genetics,  metabolism,  physiopathology
Nervous System Malformations / etiology*,  metabolism,  physiopathology
Neurons / metabolism,  pathology
Organ Size / physiology
Pituitary Gland / abnormalities,  metabolism,  physiopathology
Rats
Rats, Mutant Strains
Rats, Sprague-Dawley
Thyroid Gland / abnormalities,  metabolism,  physiopathology
Thyroid Hormones / metabolism*
Thyrotropin / metabolism
Thyrotropin-Releasing Hormone / metabolism,  secretion
Grant Support
ID/Acronym/Agency:
1 R01 NS046214-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Thyroid Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's ...
Next Document:  Role of 5-HT1-7 receptors in short- and long-term memory for an autoshaping task: intrahippocampal m...