Document Detail


Inherited factor X deficiency: presentation of a case with etiologic and treatment considerations.
MedLine Citation:
PMID:  6227859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first documented case of inherited factor X deficiency in the dental literature is presented. Its ascertainment as a result of postoperative surgical complications illustrates the clinician's need to be familiar with the hereditary bleeding diatheses, as treatment is dependent on the underlying etiology of the specific disorder. In the present case treatment included administration of the antifibrinolytic agent epsilon-aminocaproic acid (EACA) and fresh frozen plasma. On the basis of our findings, a minimal therapeutic level of circulating factor X is estimated to be 15 percent of the normal level. Genetic heterogeneity within the factor X deficiency phenotype is discussed and, on the basis of laboratory findings, a CRM-positive autosomal recessive structural or regulator gene defect is proposed as the etiologic factor in the current case. Forty-nine cases in the literature are reviewed to delineate the pattern of bleeding in hereditary factor X deficiency.
Authors:
J R Eastman; D A Triplett; A R Nowakowski
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  56     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  461-6     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Dental Care for Disabled / methods
Factor X Deficiency / diagnosis,  drug therapy,  genetics,  physiopathology*
Humans
Hypoprothrombinemias / physiopathology*
Male
Oral Hemorrhage / prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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