| Inherited cardiac arrhythmias: diagnosis, treatment, and prevention. | |
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MedLine Citation:
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PMID: 21977220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The incidence of sudden cardiac death in persons under age 40 is roughly 3 per 100 000 persons per year in Germany and North America. Many of these deaths are found to be due to hereditary heart diseases, often a primary structural heart disease associated with arrhythmia or else a primary arrhythmia syndrome in a structurally normal heart. Such diseases are usually of autosomal dominant inheritance, often affect otherwise healthy persons, and can generally be well treated if recognized early. Patients commonly have affected relatives who are still asymptomatic. METHODS: This review is based on articles up to May 2010 that were retrieved by a selective search of the Medline database via PubMed, with additional consideration of the relevant European and American guidelines and the German Law on Genetic Diagnosis. RESULTS AND CONCLUSION: Hereditary arrhythmia syndromes are now found in more than half of all initially unexplained cases of sudden cardiac death in young persons. Among such cases, the hereditary arrhythmia syndrome is primary in 70% and caused by an arrhythmogenic structural heart disease in 30%. In addition to autopsy findings, a thorough family history, relevant medical findings obtained during life (if available), the examination of relatives, and directed molecular testing where appropiate enabled establishing the diagnosis. Arrthymia syndromes that can cause sudden death are often detectable during life if physicians and the public are appropriately sensitized. |
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Authors:
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Britt-Maria Beckmann; Arne Pfeufer; Stefan Kääb |
Publication Detail:
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Type: Journal Article; Review Date: 2011-09-16 |
Journal Detail:
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Title: Deutsches Ärzteblatt international Volume: 108 ISSN: 1866-0452 ISO Abbreviation: Dtsch Arztebl Int Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-06 Completed Date: 2012-04-25 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101475967 Medline TA: Dtsch Arztebl Int Country: Germany |
Other Details:
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Languages: eng Pagination: 623-33; quiz 634 Citation Subset: IM |
Affiliation:
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Medizinische Klinik und Poliklinik 1, Ludwig-Maximilians-Universität München. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arrhythmias, Cardiac / diagnosis, genetics*, mortality, therapy Arrhythmogenic Right Ventricular Dysplasia / diagnosis, genetics Cardiomyopathy, Dilated / diagnosis, genetics Cardiomyopathy, Hypertrophic* / diagnosis, genetics Child Cooperative Behavior Cross-Sectional Studies DNA Mutational Analysis Diagnosis, Differential Early Diagnosis Echocardiography Electrocardiography Genetic Testing Humans Incidence Interdisciplinary Communication Isolated Noncompaction of the Ventricular Myocardium / diagnosis, genetics Long QT Syndrome / diagnosis, genetics, mortality, therapy Signal Processing, Computer-Assisted |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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