| Inherited and acquired thrombophilia: pregnancy outcome and treatment. | |
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MedLine Citation:
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PMID: 16797917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal thrombophilias increases the risk of an adverse pregnancy outcome. An extensive literature review highlights the role of inherited and acquired thrombophilic disorders in spontaneous abortion, both early and late, recurrent or isolate, in intrauterine growth retardation, in placenta abruption, in pre-eclampsia and in venous thromboembolism. We have particularly focused attention on the following factors: antithrombin III (ATIII), proteins C (PC) and S (PS) deficiencies, genetic mutations particularly factor V Leiden (FVL), prothrombin gene G20210A (PTM) and the thermolabile variant of the methylene tetrahydrofolate reductase C677T (MTHFR) gene, lupus anticoagulant (LAC) and anticardiolipin antibodies, VIIIc factor, hyperhomocysteinemia and acquired activated protein C resistance. Appropriate treatment can improve pregnancy outcome without teratogenic effects. |
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Authors:
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Marco De Santis; A F Cavaliere; G Straface; E Di Gianantonio; A Caruso |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-06-23 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 22 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-10 Completed Date: 2006-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
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Telefono Rosso-Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo A. Gemelli, 8, 00168 Rome, Italy. marcodesantis@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Abruptio Placentae / etiology Anticoagulants / therapeutic use Aspirin / therapeutic use Female Fetal Growth Retardation / etiology Heparin / therapeutic use Humans Pre-Eclampsia / etiology Pregnancy Thrombophilia / complications*, congenital, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 50-78-2/Aspirin; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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