Document Detail


Inherited and acquired thrombophilia: pregnancy outcome and treatment.
MedLine Citation:
PMID:  16797917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal thrombophilias increases the risk of an adverse pregnancy outcome. An extensive literature review highlights the role of inherited and acquired thrombophilic disorders in spontaneous abortion, both early and late, recurrent or isolate, in intrauterine growth retardation, in placenta abruption, in pre-eclampsia and in venous thromboembolism. We have particularly focused attention on the following factors: antithrombin III (ATIII), proteins C (PC) and S (PS) deficiencies, genetic mutations particularly factor V Leiden (FVL), prothrombin gene G20210A (PTM) and the thermolabile variant of the methylene tetrahydrofolate reductase C677T (MTHFR) gene, lupus anticoagulant (LAC) and anticardiolipin antibodies, VIIIc factor, hyperhomocysteinemia and acquired activated protein C resistance. Appropriate treatment can improve pregnancy outcome without teratogenic effects.
Authors:
Marco De Santis; A F Cavaliere; G Straface; E Di Gianantonio; A Caruso
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-06-23
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  22     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Affiliation:
Telefono Rosso-Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo A. Gemelli, 8, 00168 Rome, Italy. marcodesantis@rm.unicatt.it
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Abruptio Placentae / etiology
Anticoagulants / therapeutic use
Aspirin / therapeutic use
Female
Fetal Growth Retardation / etiology
Heparin / therapeutic use
Humans
Pre-Eclampsia / etiology
Pregnancy
Thrombophilia / complications*,  congenital,  drug therapy*
Chemical
Reg. No./Substance:
0/Anticoagulants; 50-78-2/Aspirin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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