Document Detail

Inheritance of myotonic discharges in American quarter horses and the relationship to hyperkalemic periodic paralysis.
MedLine Citation:
PMID:  1586896     Owner:  NLM     Status:  MEDLINE    
Electromyography (EMG) was used to detect myotonic discharges in Quarter Horse breeding stock and to follow the results of mating horses with hyperkalemic periodic paralysis (HPP). The studies were performed on two brood mare farms. A total of six breeding stock showed myotonic discharges and 15 were nonmyotonic. Myotonic discharges were seen in five of six horses belonging to the blood line previously implicated as being predisposed to HPP. Two of these horses had shown clinical signs of HPP. Only one of 15 breeding horses unrelated to the HPP predisposed blood line showed myotonic discharges. When both parents were non-myotonic on EMG than the F1 generation (n = 6) were also nonmyotonic. When a stallion with HPP and myotonic discharges was mated to eight nonmyotonic mares over a six year period half the animals of the F1 generation (n = 25) showed myotonic discharges. When both parents showed myotonic discharges four F1 offspring were myotonic and two were nonmyotonic on EMG testing. There was no evidence of sex linkage. The results are consistent with an autosomal dominant mode of inheritance. Hyperkalemic periodic paralysis and myotonic discharges on EMG may be different manifestations of the same underlying defect.
J M Naylor; J A Robinson; E C Crichlow; J E Steiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  56     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-25     Completed Date:  1992-06-25     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
Department of Veterinary Internal Medicine, University of Saskatchewan.
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MeSH Terms
Electromyography / veterinary
Horse Diseases / genetics*
Hyperkalemia / genetics,  veterinary*
Myotonia Congenita / genetics,  veterinary*
Paralyses, Familial Periodic / genetics,  veterinary*
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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