Document Detail

Inhaled whole exhaust and its effect on exercise performance and vascular function.
MedLine Citation:
PMID:  21867399     Owner:  NLM     Status:  Publisher    
Context: Internal combustion engines are a major source of particulate matter (PM) which has been shown to result in vasoconstriction, yet no present study to our knowledge has investigated the effect of exhaust emissions on both exercise performance and the vasculature. Objective: To examine the effect of freshly generated whole exhaust on exercise performance, pulmonary arterial pressure (PP), and flow-mediated vasodilation (FMD) of the brachial artery. Materials and Methods: Sixteen male, collegiate athletes (age: 20.8 ± 1.28 years) were randomly assigned to submaximal exercise for 20 min followed by a 6 min maximal work accumulation exercise test in either high PM (HPM) or low PM (LPM) conditions on two consecutive days. After a 7-day washout period, subjects completed identical exercise trials in the alternate condition. HPM conditions were generated from a 4-cycle gasoline engine. The participants' PP and FMD were assessed before and after each exercise trial by tricuspid regurgitant velocity and brachial artery imaging, respectively. Results: Total work (LPM: 108.0 ± 14.8 kJ; HPM: 104.9 ± 15.2kJ, p = 0.019) and FMD (LPM: 8.17 ± 6.41%; HPM: 6.59 ± 2.53%; p = 0.034) significantly decreased in HPM while PP was significantly increased (LPM: 16.9 ± 1.13 mmHg; HPM: 17.9 ± 1.70 mmHg; p = 0.004). A significant correlation was identified between the change in exercise performance and the change in FMD (r = 0.494; p = 0.026) after the first HPM trial. Conclusion: Exercise performance declined in HPM conditions in part due to impaired vasodilation in the peripheral vasculature.
Paul T Cutrufello; Kenneth W Rundell; James M Smoliga; Georgios A Stylianides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-25
Journal Detail:
Title:  Inhalation toxicology     Volume:  -     ISSN:  1091-7691     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The University of Scranton, Scranton , PA , USA.
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