| Inhaled steroids improve quality of life in patients with steady-state bronchiectasis. | |
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MedLine Citation:
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PMID: 16434174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effects of inhaled steroids upon the quality of life of patients with bronchiectasis remain unknown. STUDY OBJECTIVE: To analyze the effect of inhaled fluticasone propionate (FP) for 6 months upon the clinical, functional, microbiological and outcome parameters of patients with steady-state bronchiectasis not due to cystic fibrosis, and its repercussions for patient health-related quality of life (HRQoL). DESIGN: Prospective, randomized, double-blind (for effective doses) study. PATIENTS AND INTERVENTIONS: The diagnosis of bronchiectasis was made by high-resolution computed tomography. Ninety-three patients (mean age: 68.5 [8.4]) were randomized to receive 250 microg bid, 500 microg bid or no treatment with inhaled FP for 6 months. Data were collected at baseline and at 1, 3 and 6 months after the start of treatment. HRQoL was assessed using the validated Spanish version of the St. George's Respiratory Questionnaire. RESULTS: The group administered FP 1000 microg daily showed significant improvement in dyspnea (1.03 [2.1]-1.24 [2.2] points; P = 0.01-0.04), sputum production (P = 0.001), days without cough (P = 0.02) and short-acting beta-2 agonists used (P = 0.01) from the first month of treatment, with no changes in pulmonary function, number or severity of exacerbations, or microbiological profile of the sputum. As a result, an improvement in HRQoL was seen in this group after 3 months of treatment (45.4 [14.2] vs. 40.5 [13.9]; P = 0.01). CONCLUSIONS: Inhalatory FP 500 microg bid is effective from the first month of treatment for controlling the symptoms of patients with steady-state bronchiectasis-thus ensuring a significant improvement in HRQoL. |
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Authors:
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Miguel A Martínez-García; Miguel Perpiñá-Tordera; Pilar Román-Sánchez; Juan Jose Soler-Cataluña |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-01-24 |
Journal Detail:
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Title: Respiratory medicine Volume: 100 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2007-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1623-32 Citation Subset: IM |
Affiliation:
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Pneumology Unit, Requena General Hospital, Valencia, Spain. med013413@nacom.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aged Androstadienes / administration & dosage* Bronchiectasis / drug therapy* Bronchodilator Agents / administration & dosage* Cough / drug therapy Double-Blind Method Dyspnea / drug therapy Female Forced Expiratory Volume Humans Male Prospective Studies Quality of Life Respiratory Sounds Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Bronchodilator Agents; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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