Document Detail


Inhaled salbutamol and endurance cycling performance in non-asthmatic athletes.
MedLine Citation:
PMID:  15459835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Beta(2)-adrenergic agonists are important therapeutic agents for the prevention and treatment of (exercise-induced) asthma in athletes, but may have ergogenic effects. In this study we investigated whether inhalation of a supra-therapeutic dose of 800 microg salbutamol before exercise affects endurance performance during a cycling trial in non-asthmatic athletes. In a double-blind, randomized cross-over study, 16 athletes performed two trials, where they had to perform a certain amount of work as fast as possible on a cycle ergometer, 30 minutes after inhalation of 800 micro g salbutamol or placebo. Peak expiratory flow (PEF), forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV(1)) were measured before and after exercise and blood samples were obtained before and during exercise. Cycling performance time was 4010.2 +/- 327.7 s after placebo inhalation and 3927.6 +/- 231.3 s after inhalation salbutamol (p < 0.05). Although salbutamol inhalation increased plasma free fatty acids, glycerol and lactate concentrations and decreased plasma potassium concentrations at rest, no differences between placebo and salbutamol in these variables were found during exercise. PEF and FEV(1) were increased after salbutamol inhalation at rest compared with placebo, but the difference between placebo and salbutamol after exercise was no longer significant. Inhalation of a supratherapeutic dose of 800 micro g salbutamol improved endurance cycling performance by 1.9 +/- 1.8 % in non-asthmatic athletes, which indicates that this route of administration does not exclude the possibility of an ergogenic effect of beta(2)-adrenergic agents in athletes. The increase in performance was not explained by changes in plasma concentrations of free fatty acids, glycerol, lactate, and potassium during exercise or by changes in ventilatory parameters at rest and after exercise. Therefore, the mechanism of the increase in performance remains to be determined.
Authors:
M A van Baak; O M de Hon; F Hartgens; H Kuipers
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of sports medicine     Volume:  25     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
Affiliation:
Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands. m.vanbaak@hb.unimaas.nl
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adult
Albuterol / administration & dosage,  pharmacology*
Bicycling / physiology*
Bronchodilator Agents / administration & dosage,  pharmacology*
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Fatty Acids / blood
Glycerol / blood
Humans
Lactic Acid / blood
Male
Physical Endurance / drug effects*
Potassium / blood
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Fatty Acids; 18559-94-9/Albuterol; 50-21-5/Lactic Acid; 56-81-5/Glycerol; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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