| Inhaled nitric oxide use in bidirectional Glenn anastomosis for elevated Glenn pressures. | |
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MedLine Citation:
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PMID: 16564287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Children frequently undergo bidirectional Glenn anastomosis in the staged surgical management of single ventricle physiology. The purpose of our study was to investigate the role of inhaled nitric oxide therapy in children with marked elevations in Glenn pressures after this surgery. METHODS: A retrospective study over a 30-month period was performed. The effect of inhaled nitric oxide therapy was analyzed in children with marked elevations of Glenn pressures resulting in decreased systemic perfusion. Effects on Glenn pressures, respiratory indices, and systemic perfusion were evaluated after initiation of nitric oxide therapy and compared with baseline parameters. RESULTS: Sixteen patients were placed on nitric oxide therapy for marked elevations of Glenn pressures (22.4 +/- 3.9 mm Hg). In the 11 responsive patients, there were significant reductions in Glenn pressures (from 22.4 mm Hg to 17.1 mm Hg, p < 0.001) and significant improvement in partial pressure of oxygen to fraction of inspired oxygen ratio (from 49 to 74.3, p = 0.001) and oxygenation index (from 17 to 12, p = 0.005). There was simultaneous significant reduction in inotrope score (from 14.9 to 11.4, p < 0.001) and fluid volume support (from 11.4 mL/kg to 2.3 mL/kg, p < 0.001) in the responsive patients. Five patients that failed to show any response were found, subsequently, to have an anatomic lesion. CONCLUSIONS: Inhaled nitric oxide produces significant reduction in Glenn pressures and improvement in systemic perfusion and pulmonary gas exchange in patients with marked elevations of Glenn pressures after bidirectional Glenn anastomosis. Patients who fail to respond should be investigated for an anatomic lesion. |
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Authors:
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Hemant S Agarwal; Kevin B Churchwell; Thomas P Doyle; Karla G Christian; Davis C Drinkwater; Daniel W Byrne; Mary B Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 81 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-27 Completed Date: 2006-06-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1429-34 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Critical Care, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. hemant.agarwal@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Anastomosis, Surgical / adverse effects, methods Female Humans Hypertension / drug therapy*, etiology Infant Male Nitric Oxide / administration & dosage* Pulmonary Artery / surgery* Retrospective Studies Vascular Surgical Procedures / adverse effects, methods Vena Cava, Superior / surgery* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR-00095/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 2006 Apr;81(4):1434-5
[PMID:
16564288
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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