| Inhaled nitric oxide for oligohydramnios-induced pulmonary hypoplasia: a report of two cases and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 11840249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We describe the clinical courses of two premature infants, a male born at 29(4/7) weeks' gestational age after an 8-week period of rupture of membranes (ROM) and severe oligohydramnios, and a female infant born at 31 weeks' gestational age after an 18-week period of ROM and severe oligohydramnios. Within hours after birth, despite intubation and aggressive ventilation, both infants developed fulminant hypoxic respiratory failure. Their clinical courses were consistent with pulmonary hypertension and both infants were transferred for trials of inhaled nitric oxide (iNO). Both infants had dramatic responses to iNO, suggesting that the pulmonary disease seen after prolonged oligohydramnios may have a component of nitric oxide-sensitive pulmonary hypertension. The goals of this article are to (1) review oligohydramnios-induced pulmonary hypoplasia, (2) discuss patients at highest mortality risk, and (3) describe the effects of iNO on pulmonary hypertension in infants with hypoxemia following prolonged ROM and severe oligohydramnios. |
| | |
Authors:
|
Cara Geary; Jeffrey Whitsett |
Related Documents
:
|
21669959 - Secondhand smoke risk in infants discharged from a nicu: potential for significant heal... 3658529 - Pulmonary function at 1 year of age in survivors of neonatal respiratory distress: a mu... 18166309 - Systemic fetal inflammation and reduced concentrations of macrophage migration inhibito... 20216169 - Neonatal pulmonary hypertension. 2780129 - Neck and body position effects on pulmonary mechanics in infants. 9229159 - Pulmonary hemorrhage in infants and children. 3399049 - Comments on lindesay: laterality shift in homosexual men. 2286679 - The measurement of death depression. 17937739 - Treatment differences between aboriginal and white infants admitted to canadian neonata... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 22 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2002 Jan |
Date Detail:
|
Created Date: 2002-02-12 Completed Date: 2002-03-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
|
Languages: eng Pagination: 82-5 Citation Subset: IM |
Affiliation:
|
Divisions of Neonatology and Pulmonary Biology, Children's Hospital Medical Center and Good Samaritan Hospital, Cincinnati, OH 45229-3039, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Betamethasone
/
therapeutic use Female Fetal Membranes, Premature Rupture / drug therapy Fetal Organ Maturity Glucocorticoids / therapeutic use Humans Hypertension, Pulmonary / therapy* Infant, Newborn Lung / abnormalities* Male Nitric Oxide / administration & dosage* Oligohydramnios / complications* Pregnancy Respiration, Artificial Respiratory Distress Syndrome, Newborn / therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 10102-43-9/Nitric Oxide; 378-44-9/Betamethasone |
| Comments/Corrections | |
Comment In:
|
J Perinatol. 2002 Sep;22(6):510
[PMID:
12168134
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Breast-feeding promotion interventions: good public health and economic sense.
Next Document: Fetal demise due to herpes simplex virus: an illustrated case report.