Document Detail

Inhaled nitric oxide in combination with volume resuscitation refines a porcine model of endotoxic shock.
MedLine Citation:
PMID:  12120968     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Existing porcine models of endotoxic shock poorly represent the human situation. AIMS: To assess whether the cardiovascular profile of a porcine model could be improved by refining the protocol. METHODS: In 30 pigs, right and left heart pressures and cardiac output were measured. Lipopolysaccharide (LPS) was administered as a bolus (n=12), as a 30 minute infusion (n=6) or as a 30 minute infusion along with inhaled NO and volume resuscitation (n=6) and six sham-treated pigs received normal saline. Haemodynamic values were measured over three hours. RESULTS: LPS increased pulmonary vascular resistance (PVR) (13.3 +/- 1.4 to 37.0 +/- 3.9kPa/l per sec, p<0.05) and reduced cardiac output (6.0 +/- 0.6 to 4.8 +/- 0.41/min). Mortality was 50% within 30 minutes. Inhaled NO and volume resuscitation controlled pulmonary vascular resistance (PVR) and preserved CO. Systemic vascular resistance (SVR) declined in the first hour (118.4 +/- 11.8 to 65.8 +/- 8.2kPa/l per sec, p<0.05) and remained low. CONCLUSIONS: Porcine models of endotoxaemia based on LPS administration are a poor model of human septic shock, but can be improved by regulating PVR and supporting CO which may contribute to future studies of septic shock
N A Herity; J D Allen; B Silke; A A Adgey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Irish journal of medical science     Volume:  170     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    2001 Jul-Sep
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  IM    
Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland.
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MeSH Terms
Administration, Inhalation
Cardiovascular System / drug effects,  physiopathology
Disease Models, Animal*
Escherichia coli
Fluid Therapy*
Hemodynamics / drug effects
Nitric Oxide / administration & dosage,  pharmacology*
Nitrites / blood
Shock, Septic / physiopathology,  therapy*
Reg. No./Substance:
0/Lipopolysaccharides; 0/Nitrites; 10102-43-9/Nitric Oxide

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