| Inhaled nitric oxide in burn patients with respiratory failure. | |
| | |
MedLine Citation:
|
PMID: 9137249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Inhaled nitric oxide (NO) has the potential to improve ventilation/perfusion matching and decrease pulmonary artery pressure in patients with profound respiratory failure. METHODS: Eight patients, average age of 35 years (range, 2.5-77 years) and burn size 49% (range, 19-80%), with inhalation injury and respiratory failure failing conventional management (average Pao2/FiO2 ratio (PFR) 85) were given inhaled NO at 20 ppm. RESULTS: An immediate mean increase in PFR of 10% and a decrease in pulmonary artery mean pressure of 7.8% was noted. At 24 hours, the average improvement in PFR was 28% and that in pulmonary artery mean pressure was 7.7%. Although not reaching statistical significance, these changes were more pronounced in those patients who went on to survive. There was no hypotension attributed to NO administration, and maximum methemoglobin levels averaged 0.9%. CONCLUSIONS: Inhaled NO can be safely administered to selected burn patients with severe respiratory failure who are perceived to be failing conventional support. Although current data are not adequate to support its general use, an immediate and sustained improvement in PFR and pulmonary artery mean pressure may correlate with eventual recovery of pulmonary function. Continued evaluation in controlled settings seems warranted and is in progress. |
| | |
Authors:
|
R L Sheridan; W E Hurford; R M Kacmarek; R H Ritz; L M Yin; C M Ryan; R G Tompkins |
Related Documents
:
|
19619419 - Comparison of 3 methods to induce acute pulmonary hypertension in pigs. 2764149 - Left atrial hypertension causes pleural effusion formation in unanesthetized sheep. 8497209 - In vivo effects of intravascularly applied escherichia coli hemolysin: dissociation bet... 1124859 - Isoproterenol aerosols. 18082509 - Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistan... 14636929 - Echocardiographic determination of mean pulmonary artery pressure. 7997569 - Flow-augmentation device for peripheral vascular doppler us. 1684039 - The effect of multiple doses of phenylpropanolamine on the blood pressure of patients w... 21810419 - Interaction of a-240t and a2350g related genotypes of angiotensin-converting enzyme (ac... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of trauma Volume: 42 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1997 Apr |
Date Detail:
|
Created Date: 1997-05-22 Completed Date: 1997-05-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 629-34 Citation Subset: AIM; IM |
Affiliation:
|
Surgical Service, Massachusetts General Hospital, Boston, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Adolescent Adult Aged Burns, Inhalation / complications* Child Child, Preschool Drug Monitoring Humans Middle Aged Nitric Oxide / therapeutic use* Pulmonary Wedge Pressure / drug effects Respiratory Insufficiency / drug therapy*, etiology*, mortality, physiopathology Survival Analysis Ventilation-Perfusion Ratio / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
P50 GM21700/GM/NIGMS NIH HHS; T32 GM07035/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prospective study investigating routine usage of ultrasonography as the initial diagnostic modality ...
Next Document: CD4- CD8- TCR alpha/beta+ suppressor T cells demonstrated in mice 1 day after thermal injury.