Document Detail

Inhaled nitric oxide: effects on cerebral growth and injury in a baboon model of premature delivery.
MedLine Citation:
PMID:  17413862     Owner:  NLM     Status:  MEDLINE    
Inhaled nitric oxide (iNO) enhances ventilation in very preterm infants, but the effects on the brain remain uncertain. We evaluated the impact of iNO on brain growth and cerebral injury in a premature baboon model. Baboons were delivered at 125 d of gestation (term 185 d of gestation) and ventilated for 14 d with either positive pressure ventilation (PPV) (n = 7) or PPV + iNO (n = 8). Brains were assessed histologically for parameters of development and injury. Compared with gestational controls (n = 7), brain and body weights were reduced but brain-to-body weight ratios were increased in all prematurely delivered (PD) animals; the surface folding index (SFI), was reduced in PPV but not PPV + iNO animals. Compared with controls, the brain damage index was increased (p < 0.05) in both cohorts of PD animals. There was no difference between ventilatory regimens, however, in 25% of animals with iNO therapy, there were organized hematomas in the subarachnoid space. Overall, iNO did not alter the extent of brain damage but did result in the presence of hematomas. These results do not confirm any protective or major injurious effect of nitric oxide therapy on the developing brain.
Sandra M Rees; Emily J Camm; Michelle Loeliger; Sarah Cain; Sandra Dieni; Donald McCurnin; Philip W Shaul; Bradley Yoder; Catriona McLean; Terrie E Inder
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-07-16     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  552-8     Citation Subset:  IM    
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MeSH Terms
Administration, Inhalation
Animals, Newborn
Body Weight
Brain / anatomy & histology,  growth & development*,  pathology*,  physiology
Brain Injuries* / pathology,  physiopathology,  therapy
Gestational Age
Nitric Oxide* / administration & dosage,  therapeutic use
Organ Size
Premature Birth*
Grant Support
HL-52636/HL/NHLBI NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986-097326/RR/NCRR NIH HHS; R01 HL074942/HL/NHLBI NIH HHS; R01 HL074942/HL/NHLBI NIH HHS; R01 HL074942-03/HL/NHLBI NIH HHS; U01-HL063399/HL/NHLBI NIH HHS
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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