| Inhaled nitric oxide attenuates acute lung injury via inhibition of nuclear factor-kappa B and inflammation. | |
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MedLine Citation:
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PMID: 11796694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of inhaled nitric oxide (NO) on inflammatory process in acute lung injury (ALI) is unclear. The aims of this study were to 1) examine whether inhaled NO affects the biochemical lung injury parameters and cellular inflammatory responses and 2) determine the effect of inhaled NO on the activation of nuclear factor-kappa B (NF-kappa B) in lipopolysaccharide (LPS)-induced ALI. Compared with saline controls, rabbits treated intravenously with LPS showed increases in total protein and lactate dehydrogenase in the bronchoalveolar lavage (BAL) fluid, indicating ALI. LPS-treated animals with NO inhalation (LPS-NO) showed significant decreases in these parameters. Neutrophil numbers in the BAL fluid, the activity of reactive oxygen species in BAL cells, and the levels of interleukin (IL)-1 beta and IL-8 in alveolar macrophages were increased in LPS-treated animals. In contrast, neutrophil numbers and these cellular activities were substantially decreased in LPS-NO animals, compared with LPS-treated animals. NF-kappa B activation in alveolar macrophages from LPS-treated animals was also markedly increased, whereas this activity was effectively blocked in LPS-NO animals. These results suggest that inhaled NO attenuates LPS-induced ALI and pulmonary inflammation. This attenuation may be associated with the inhibition of NF-kappa B activation. |
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Authors:
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Jihee Lee Kang; Wann Park; In Soon Pack; Hui Su Lee; Mi Jung Kim; Chae-Man Lim; Younsuck Koh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 92 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-17 Completed Date: 2002-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 795-801 Citation Subset: IM |
Affiliation:
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Division of Cell Biology, Department of Physiology, College of Medicine, Ewha Medical Research Center, Ewha Women's University, Seoul 158-056, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Inhalation Animals Bronchoalveolar Lavage Fluid / chemistry Cell Movement / drug effects Interleukin-1 / metabolism Interleukin-8 / metabolism L-Lactate Dehydrogenase / metabolism Lipopolysaccharides Macrophages, Alveolar / metabolism NF-kappa B / antagonists & inhibitors*, physiology Neutrophils / physiology Nitric Oxide / administration & dosage*, pharmacology Pneumonia / chemically induced, metabolism*, pathology* Proteins / metabolism Rabbits Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-8; 0/Lipopolysaccharides; 0/NF-kappa B; 0/Proteins; 0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide; EC 1.1.1.27/L-Lactate Dehydrogenase |
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