Document Detail


Inhaled lysine acetylsalicylate (L-ASA) attenuates the bronchoconstrictor response to adenosine 5'-monophosphate (AMP) in asthmatic subjects.
MedLine Citation:
PMID:  7589376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When administered by inhalation, adenosine 5'-monophosphate (AMP) provokes dose-related bronchoconstriction in asthmatic subjects by a mechanism believed to involve mast cell mediator release. However, little is known of the change in airway responsiveness to AMP after cyclo-oxygenase blockade. The aim of this study was to investigate the effect of the potent cyclo-oxygenase inhibitor, lysine acetylsalicylate (L-ASA) administered by inhalation, on AMP-induced bronchoconstriction in a group of nine asthmatic subjects. The subjects studied attended the laboratory on six separate occasions to receive nebulized L-ASA (solution of 90 mg.ml-1) or matched placebo (glycine solution, 30 mg.ml-1) 15 min prior to bronchoprovocation tests with AMP, histamine and methacholine in a randomized, double-blind order. Changes in airway calibre were followed as forced expiratory volume in one second (FEV1) and agonist responsiveness was expressed as the provocative concentration causing a 20% fall in FEV1 from baseline (PC20). Administration of both L-ASA and glycine solution caused a small but significant acute fall in FEV1 from baseline, which returned to normal within 15 min. When compared to placebo, inhaled L-ASA reduced the airway responsiveness to AMP in all the subjects studied, the geometric mean (range) values for PC20 AMP increasing significantly from 36.3 (7.9-250.5) to 101.8 (27.2-1300) mg.ml-1 after placebo and L-ASA, respectively. Moreover, nebulized L-ASA induced a small but significant reduction in airway responsiveness to histamine, the geometric mean (range) PC20 values for histamine increasing from 2.77 (1.05-5.49) to 4.36 (1.69-11.24) mg.ml-1 after placebo and L-ASA, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
N Crimi; R Polosa; S Magrì; G Prosperini; V L Milazzo; G Santonocito; A Mistretta
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European respiratory journal     Volume:  8     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-27     Completed Date:  1995-11-27     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  905-12     Citation Subset:  IM    
Affiliation:
Istituto Malattie Apparato Respiratorio, Università di Catania, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Monophosphate / pharmacology*
Administration, Inhalation
Adult
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology*,  therapeutic use
Aspirin / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Asthma / drug therapy*,  physiopathology
Bronchial Provocation Tests
Bronchoconstriction / drug effects*
Cyclooxygenase Inhibitors / administration & dosage,  pharmacology*,  therapeutic use
Double-Blind Method
Drug Interactions
Female
Histamine / pharmacology
Humans
Lysine / administration & dosage,  analogs & derivatives*,  pharmacology,  therapeutic use
Male
Methacholine Chloride / pharmacology
Middle Aged
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 51-45-6/Histamine; 56-87-1/Lysine; 61-19-8/Adenosine Monophosphate; 62-51-1/Methacholine Chloride

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