| Inhaled lysine acetylsalicylate (L-ASA) attenuates the bronchoconstrictor response to adenosine 5'-monophosphate (AMP) in asthmatic subjects. | |
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MedLine Citation:
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PMID: 7589376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When administered by inhalation, adenosine 5'-monophosphate (AMP) provokes dose-related bronchoconstriction in asthmatic subjects by a mechanism believed to involve mast cell mediator release. However, little is known of the change in airway responsiveness to AMP after cyclo-oxygenase blockade. The aim of this study was to investigate the effect of the potent cyclo-oxygenase inhibitor, lysine acetylsalicylate (L-ASA) administered by inhalation, on AMP-induced bronchoconstriction in a group of nine asthmatic subjects. The subjects studied attended the laboratory on six separate occasions to receive nebulized L-ASA (solution of 90 mg.ml-1) or matched placebo (glycine solution, 30 mg.ml-1) 15 min prior to bronchoprovocation tests with AMP, histamine and methacholine in a randomized, double-blind order. Changes in airway calibre were followed as forced expiratory volume in one second (FEV1) and agonist responsiveness was expressed as the provocative concentration causing a 20% fall in FEV1 from baseline (PC20). Administration of both L-ASA and glycine solution caused a small but significant acute fall in FEV1 from baseline, which returned to normal within 15 min. When compared to placebo, inhaled L-ASA reduced the airway responsiveness to AMP in all the subjects studied, the geometric mean (range) values for PC20 AMP increasing significantly from 36.3 (7.9-250.5) to 101.8 (27.2-1300) mg.ml-1 after placebo and L-ASA, respectively. Moreover, nebulized L-ASA induced a small but significant reduction in airway responsiveness to histamine, the geometric mean (range) PC20 values for histamine increasing from 2.77 (1.05-5.49) to 4.36 (1.69-11.24) mg.ml-1 after placebo and L-ASA, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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N Crimi; R Polosa; S Magrì; G Prosperini; V L Milazzo; G Santonocito; A Mistretta |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The European respiratory journal Volume: 8 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-11-27 Completed Date: 1995-11-27 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 905-12 Citation Subset: IM |
Affiliation:
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Istituto Malattie Apparato Respiratorio, Università di Catania, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Monophosphate
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pharmacology* Administration, Inhalation Adult Analysis of Variance Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology*, therapeutic use Aspirin / administration & dosage, analogs & derivatives*, pharmacology, therapeutic use Asthma / drug therapy*, physiopathology Bronchial Provocation Tests Bronchoconstriction / drug effects* Cyclooxygenase Inhibitors / administration & dosage, pharmacology*, therapeutic use Double-Blind Method Drug Interactions Female Histamine / pharmacology Humans Lysine / administration & dosage, analogs & derivatives*, pharmacology, therapeutic use Male Methacholine Chloride / pharmacology Middle Aged Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 51-45-6/Histamine; 56-87-1/Lysine; 61-19-8/Adenosine Monophosphate; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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