| Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products. | |
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MedLine Citation:
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PMID: 7664860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhaled frusemide protects asthmatic airways against a wide variety of bronchoconstrictor stimuli by unknown mechanisms. To investigate whether inhaled loop diuretics modulate baseline bronchial responsiveness, a randomized, double-blind, placebo-controlled study was conducted to test the ability of frusemide (40 mg) and bumetanide (2 mg) to displace concentration-response curves with methacholine in 14 healthy volunteers. In addition, separate randomized, double-blind studies were carried out to evaluate the effects of oral flurbiprofen, a potent cyclo-oxygenase inhibitor, on the protective action of frusemide against methacholine-induced bronchoconstriction. Inhaled loop diuretics significantly increased the provocative concentration of methacholine causing a 15% decrease in forced expiratory volume in one second (PC15FEV1) from the geometric mean (range) value of 58.6 (9.2-233) mg.ml-1 after placebo administration, to 129 (13.8-505) and to 106 (6.6-510) mg.ml-1 after administration of frusemide and bumetanide, respectively. Similar results were obtained when data from partial flow-volume curves were used for analysis. In the eight subjects studied, pretreatment with oral placebo and inhaled frusemide reduced airway responsiveness to methacholine, with a geometric mean (range) PC15FEV1 value of 116 (25.4-405) mg.ml-1, and premedication with oral flurbiprofen abolished this protective effect, the geometric mean (range) PC15FEV1 methacholine being reduced to a value of 50.3 (16.6-189) mg.ml-1. In addition, oral flurbiprofen alone failed to alter airway responsiveness to methacholine. In view of these findings, it is suggested that bronchoprotective prostaglandins may mediate the effects of loop diuretics against methacholine-induced bronchoconstriction in man. |
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Authors:
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R Polosa; K Rajakulasingam; G Prosperini; S Magrì; C Mastruzzo; S T Holgate |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 8 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-10-06 Completed Date: 1995-10-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 593-9 Citation Subset: IM |
Affiliation:
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Istituto Malattie Apparato Respiratorio, Università di Catania, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Administration, Oral Adult Aerosols Asthma / physiopathology Bronchial Hyperreactivity / physiopathology* Bronchial Provocation Tests Bronchoconstriction / drug effects*, physiology Bumetanide / administration & dosage*, pharmacology Double-Blind Method Female Flurbiprofen / administration & dosage, pharmacology Forced Expiratory Volume / drug effects Furosemide / administration & dosage*, pharmacology Humans Male Methacholine Chloride / diagnostic use Prostaglandins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Prostaglandins; 28395-03-1/Bumetanide; 5104-49-4/Flurbiprofen; 54-31-9/Furosemide; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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