Document Detail


Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products.
MedLine Citation:
PMID:  7664860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhaled frusemide protects asthmatic airways against a wide variety of bronchoconstrictor stimuli by unknown mechanisms. To investigate whether inhaled loop diuretics modulate baseline bronchial responsiveness, a randomized, double-blind, placebo-controlled study was conducted to test the ability of frusemide (40 mg) and bumetanide (2 mg) to displace concentration-response curves with methacholine in 14 healthy volunteers. In addition, separate randomized, double-blind studies were carried out to evaluate the effects of oral flurbiprofen, a potent cyclo-oxygenase inhibitor, on the protective action of frusemide against methacholine-induced bronchoconstriction. Inhaled loop diuretics significantly increased the provocative concentration of methacholine causing a 15% decrease in forced expiratory volume in one second (PC15FEV1) from the geometric mean (range) value of 58.6 (9.2-233) mg.ml-1 after placebo administration, to 129 (13.8-505) and to 106 (6.6-510) mg.ml-1 after administration of frusemide and bumetanide, respectively. Similar results were obtained when data from partial flow-volume curves were used for analysis. In the eight subjects studied, pretreatment with oral placebo and inhaled frusemide reduced airway responsiveness to methacholine, with a geometric mean (range) PC15FEV1 value of 116 (25.4-405) mg.ml-1, and premedication with oral flurbiprofen abolished this protective effect, the geometric mean (range) PC15FEV1 methacholine being reduced to a value of 50.3 (16.6-189) mg.ml-1. In addition, oral flurbiprofen alone failed to alter airway responsiveness to methacholine. In view of these findings, it is suggested that bronchoprotective prostaglandins may mediate the effects of loop diuretics against methacholine-induced bronchoconstriction in man.
Authors:
R Polosa; K Rajakulasingam; G Prosperini; S Magrì; C Mastruzzo; S T Holgate
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European respiratory journal     Volume:  8     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  593-9     Citation Subset:  IM    
Affiliation:
Istituto Malattie Apparato Respiratorio, Università di Catania, Italy.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Administration, Oral
Adult
Aerosols
Asthma / physiopathology
Bronchial Hyperreactivity / physiopathology*
Bronchial Provocation Tests
Bronchoconstriction / drug effects*,  physiology
Bumetanide / administration & dosage*,  pharmacology
Double-Blind Method
Female
Flurbiprofen / administration & dosage,  pharmacology
Forced Expiratory Volume / drug effects
Furosemide / administration & dosage*,  pharmacology
Humans
Male
Methacholine Chloride / diagnostic use
Prostaglandins / physiology*
Chemical
Reg. No./Substance:
0/Aerosols; 0/Prostaglandins; 28395-03-1/Bumetanide; 5104-49-4/Flurbiprofen; 54-31-9/Furosemide; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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