Document Detail

Inhaled lidocaine aerosol changes resting human breathing pattern.
MedLine Citation:
PMID:  7178704     Owner:  NLM     Status:  MEDLINE    
We compared resting breathing patterns in twelve normal humans before and after administration of aerosols of normal saline and 4% lidocaine. Experiments were performed in random order on two consecutive days in single blind fashion. At the time of the experiments, neither the subjects nor the people who analyzed the results knew the purpose of the study. Neither saline nor lidocaine aerosols produced changes in FEV1.0 or end-tidal PCO2, or, in the six subjects in whom measurements were made, changes in functional residual capacity or airway resistance. Aerosols of normal saline produced no change of ventilation (VI), breathing frequency (f), tidal volume (VT), duration of inspiration (Ti), mean inspiratory flow (VT/Ti) or the fraction of the breathing cycle devoted to inspiration (Ti/Tt). Lidocaine aerosols, on the other hand, were associated with a decrease in f (P less than 0.01), an increase in Ti (P less than 0.01), an increase in VT (P less than 0.02) and a decrease in VI (P less than 0.05), while VT/Ti and Ti/Tt were unchanged. We conclude that lidocaine aerosols, by compromising the function of vagal airway receptors, altered breathing pattern in normal resting humans, indicating that these receptors play a role in regulating breathing pattern under these circumstances. Though the changes we observed are most simply explained as being due to decreased stretch receptor activity, we cannot be certain that such was the case.
J Savoy; S Dhingra; N R Anthonisen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  50     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Local
Forced Expiratory Volume
Lidocaine / administration & dosage*,  pharmacology
Respiration / drug effects*
Time Factors
Reg. No./Substance:
0/Aerosols; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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