Document Detail

Inhaled iloprost in the treatment of pulmonary hypertension in very low birth weight infants: a report of two cases.
MedLine Citation:
PMID:  22755287     Owner:  NLM     Status:  In-Process    
We treated 2 very low birth weight (VLBW) infants with respiratory distress syndrome suffering from refractory hypoxic respiratory failure complicated with severe pulmonary hypertension with inhaled iloprost. The first infant was an 800 gram male and the second case was a 920 gram female. Echocardiography revealed a right to left shunt through patent duct in the first case; suprasystemic pulmonary arterial pressure was estimated by using tricuspid regurgitation of moderate severity in the second case. Inhaled iloprost was started in those infants when conventional therapies including the administration of exogenous surfactant and high-frequency oscillatory ventilation failed. After the commencement of therapy, the clinical condition of the infants improved dramatically. Pulmonary arterial pressure returned to normal levels within five days. We suggest that inhaled iloprost may be helpful by improving oxygenation and reducing the need for aggressive mechanical ventilation in some cases of severe hypoxaemic respiratory failure in VLBW infants.
Ibrahim Gokce; Hasan Kahveci; Zeynep Turkyilmaz; Basak Adakli; Cenap Zeybek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  62     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  388-91     Citation Subset:  IM    
Department of Paediatrics, Erzurum District Training and Research Hospital, Erzurum, Turkey.
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