Document Detail


Inhaled gases affect the ultrasound contrast produced by Albunex in anesthetized dogs.
MedLine Citation:
PMID:  8827627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In anesthetized animals maintained with isoflurane using 100% oxygen as a carrier gas, Albunex (Molecular Biosystems, Inc., San Diego, Calif.) produced no ultrasound contrast in the left ventricle after intravenous administration. The current study tested the hypothesis that the inhalation of gas mixtures with increased concentrations of oxygen decreased the quality and duration of Albunex-induced contrast. Albunex (0.22 mL/kg) was injected intravenously into anesthetized dogs (n = 9) breathing compressed air, oxygen, mixtures of oxygen and nitrogen, or combinations of oxygen and nitrous oxide. Albunex produced ultrasound contrast of shorter duration and decreased quality during the inhalation of gas mixtures containing increased amounts of oxygen. In the presence of inhaled gas mixtures containing nitrous oxide, Albunex produced no contrast in the left ventricle, regardless of the oxygen content. These data indicate that the inhalation of gas mixtures containing smaller amounts of nitrogen, compared with air, decreased the ability of Albunex to cause ultrasound contrast in the heart after intravenous administration.
Authors:
J H Wible; J K Wojdyla; G L Bales; W N McMullen; E A Geiser; D D Buss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  9     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  442-51     Citation Subset:  IM    
Affiliation:
Mallinckrodt Medical, Inc., St. Louis, MO 63134, USA.
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MeSH Terms
Descriptor/Qualifier:
Air
Albumins / diagnostic use*
Animals
Contrast Media*
Dogs
Echocardiography*
Microspheres
Nitrogen / pharmacology
Nitrous Oxide / pharmacology
Oxygen / pharmacology*
Chemical
Reg. No./Substance:
0/Albumins; 0/Albunex; 0/Contrast Media; 10024-97-2/Nitrous Oxide; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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