Document Detail

Inhaled furosemide does not alleviate respiratory effort during flow-limited exercise in healthy subjects.
MedLine Citation:
PMID:  17428714     Owner:  NLM     Status:  MEDLINE    
Expiratory muscle loading results in increased perception of respiratory effort; this response is mediated by non-vagal reflexes originating in the chest wall. Furosemide, due to its vagal effect, might not affect the perception of respiratory effort during expiratory flow-limited incremental exercise. In this study, we compared in nine healthy subjects the following determinants of exercise performance such as respiratory effort (Borg), workload (W'), ventilation (V'E), tidal volume (VT), respiratory frequency (f), and mean inspiratory flow (VT/TI), an index of central respiratory drive, during either standard incremental cycling exercise, or expiratory flow-limited incremental exercise. In addition we examined the effect of inhaled placebo, furosemide (40 or 80 mg) on the perception of respiratory effort following standard incremental cycling exercise and expiratory flow-limited incremental exercise. Compared with standard incremental cycling exercise, expiratory flow-limited incremental exercise increased the Borg score and VT/Ti, and decreased W',V'E ,VT, and f in all subjects at iso-workload. Neither placebo nor furosemide modified peak ventilatory variables, slopes, or intercepts of the relationships of the Borg score with W', V'E, VT/TI and VT during expiratory flow-limited incremental exercise. We conclude that (a) compared with standard incremental exercise, expiratory flow limited exercise increases central respiratory drive and perception of respiratory effort, and (b) furosemide does not affect the sensation of respiratory effort under the present conditions of increased drive to the respiratory muscles.
Pierantonio Laveneziana; Andrea Galarducci; Barbara Binazzi; Loredana Stendardi; Roberto Duranti; Giorgio Scano
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-03-06
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  21     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-15     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  196-200     Citation Subset:  IM    
Dipartimento di Medicina Interna, Sezione di Immunologia e Malattie dell'Apparato Respiratorio, Università degli Studi di Firenze, Viale G.B. Morgagni 85, 50134 Firenze, Italy.
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MeSH Terms
Administration, Inhalation
Cross-Over Studies
Diuretics / pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Furosemide / pharmacology*
Respiration / drug effects*
Respiratory Function Tests
Reg. No./Substance:
0/Diuretics; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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