Document Detail

Inhaled fenoterol pretreatment attenuates airway resistance response to endotracheal intubation.
MedLine Citation:
PMID:  7788204     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endotracheal intubation may induce vagal mediated bronchoconstriction. As fenoterol possesses bronchodilation effects, we studied the efficacy of fenoterol pretreatment on the increased resistance of total respiratory system (Rrs) caused by reflex bronchoconstriction in endotracheal intubation.
METHODS: Fifty patients were randomly allocated into two groups; group A (n = 25) with fenoterol inhaled and group B (n = 25) with placebo inhaled 10 min before induction. Patients were induced with sodium thiopental and vecuronium and resistance was measured 2 and 5 min after intubation with a Bicore pulmonary function monitor. Suctioning of the airway was performed 1 min before each measurement. Patients were further categorized into four conditions by smoking history and the presence of sputum in the suctionings. Condition I included patients that were smokers with no sputum collected. Condition II had non-smokers with no sputum collected. Condition III had patients with sputum collected but with no smoking history and condition IV were patients who had sputum collected and had a smoking history.
RESULTS: Patient who received fenoterol have significant lower total respiratory after intubation than those receiving placebo. There were no significant differences in post-intubation Rrs between smokers and non-smokers. Patients with sputum had the highest resistance after intubation with the placebo group. Heart rate and blood pressure were augmented in both groups.
CONCLUSIONS: Fenoterol pretreatment produced lower post-intubation Rrs after intubation when compared with the placebo group suggesting of a protective effect in vagal mediated bronchoconstriction.
R S Wu; K C Wu; Y H Tsai; R K Cheng; P P Tan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Sinica     Volume:  33     ISSN:  0254-1319     ISO Abbreviation:  Acta Anaesthesiol. Sin.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  9432542     Medline TA:  Acta Anaesthesiol Sin     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  7-14     Citation Subset:  IM    
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MeSH Terms
Administration, Inhalation
Airway Resistance / drug effects*
Blood Pressure / drug effects
Fenoterol / pharmacology*
Heart Rate / drug effects
Intubation, Intratracheal*
Middle Aged
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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