Document Detail

Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic and nongenomic mechanisms.
MedLine Citation:
PMID:  16765074     Owner:  NLM     Status:  MEDLINE    
Inhaled corticosteroids have both genomic and nongenomic actions on the tracheobronchial (airway) vasculature in patients with bronchial asthma. Genomic actions involve the activation or repression of target genes associated with inflammation, and reduce inflammatory hyperperfusion in the airway. In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction. This article reviews recent progress on the mechanisms by which inhaled corticosteroids reverse inflammatory blood flow changes in the airway in asthma.
Gabor Horvath; Szilvia Vasas; Adam Wanner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-04-28
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  20     ISSN:  1094-5539     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2007  
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM    
Department of Respiratory Medicine, Semmelweis University School of Medicine, Diosarok 1/C, Budapest 1125, Hungary.
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MeSH Terms
Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage,  pharmacology,  therapeutic use*
Asthma / genetics,  physiopathology,  prevention & control*
Gene Expression Regulation / drug effects
Models, Biological
Pulmonary Circulation / drug effects
Reg. No./Substance:
0/Adrenal Cortex Hormones

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