Document Detail


Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation.
MedLine Citation:
PMID:  1414688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of inhaled budesonide regimen (400 micrograms x 2 for 7 days), on agonist-induced platelet aggregation and secretion, was investigated in 18 volunteers. Platelet activation induced by serotonin and arachidonic acid was significantly enhanced after budesonide, as demonstrated by an increase in aggregation velocity (Vmax) and amplitude (Amax), and in arachidonic acid-induced ATP-secretion. We found no change in platelet aggregation induced by ADP, epinephrine, and A23187. With the exception of epinephrine-induced platelet aggregation, which was inhibited by 10(-5)-10(-4) M budesonide, in vitro studies revealed no influence of 10 min budesonide preincubation (10(-9)-10(-4) M) on agonist-induced platelet activation, suggesting that the ex vivo enhancement of platelet function was mediated by secondary corticosteroid mechanisms. A tentative explanation of the increased arachidonic acid-induced platelet activation, may be a budesonide-induced stimulation of cyclooxygenase. The enhanced serotonin-induced platelet aggregation may be a reflection of exogenous corticosteroid stimulation of the 5-HT2-receptor.
Authors:
L Hasselmark; R Malmgren; A Dumitrescu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  36     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Affiliation:
Department of Experimental Surgery, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / blood
Administration, Inhalation
Adult
Arachidonic Acid / pharmacology*
Bronchodilator Agents / administration & dosage,  pharmacology*
Budesonide
Drug Synergism
Female
Humans
Male
Middle Aged
Platelet Activation / drug effects
Platelet Aggregation / drug effects*
Platelet Count / drug effects
Pregnenediones / administration & dosage,  pharmacology*
Serotonin / pharmacology*
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Pregnenediones; 50-67-9/Serotonin; 506-32-1/Arachidonic Acid; 51333-22-3/Budesonide; 56-65-5/Adenosine Triphosphate

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