Document Detail

Inhaled nitric oxide therapy increases blood nitrite, nitrate, and s-nitrosohemoglobin concentrations in infants with pulmonary hypertension.
MedLine Citation:
PMID:  21907348     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure the circulating concentrations of nitric oxide (NO) adducts with NO bioactivity after inhaled NO (iNO) therapy in infants with pulmonary hypertension.
STUDY DESIGN: In this single center study, 5 sequential blood samples were collected from infants with pulmonary hypertension before, during, and after therapy with iNO (n = 17). Samples were collected from a control group of hospitalized infants without pulmonary hypertension (n = 16) and from healthy adults for comparison (n = 12).
RESULTS: After beginning iNO (20 ppm) whole blood nitrite levels increased approximately two-fold within 2 hours (P<.01). Whole blood nitrate levels increased to 4-fold higher than baseline during treatment with 20 ppm iNO (P<.01). S-nitrosohemoglobin increased measurably after beginning iNO (P<.01), whereas iron nitrosyl hemoglobin and total hemoglobin-bound NO-species compounds did not change.
CONCLUSION: Treatment of pulmonary hypertensive infants with iNO results in increases in levels of nitrite, nitrate, and S-nitrosohemoglobin in circulating blood. We speculate that these compounds may be carriers of NO bioactivity throughout the body and account for peripheral effects of iNO in the brain, heart, and other organs.
Yomna I Ibrahim; Janet R Ninnis; Andrew O Hopper; Douglas D Deming; Amy X Zhang; Jason L Herring; Lawrence C Sowers; Timothy J McMahon; Gordon G Power; Arlin B Blood
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-09-09
Journal Detail:
Title:  The Journal of pediatrics     Volume:  160     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-13     Completed Date:  2012-02-28     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Administration, Inhalation
Hemoglobins / metabolism*
Hypertension, Pulmonary / blood,  drug therapy*
Infant, Newborn
Nitrates / blood*
Nitric Oxide / administration & dosage,  pharmacology*
Nitrites / blood*
Treatment Outcome
Vasodilator Agents / administration & dosage,  pharmacology*
Grant Support
Reg. No./Substance:
0/Hemoglobins; 0/Nitrates; 0/Nitrites; 0/S-nitrosohemoglobin; 0/Vasodilator Agents; 31C4KY9ESH/Nitric Oxide

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