Document Detail

Inhaled Iloprost as a Rescue Therapy for Transposition of the Great Arteries With Persistent Pulmonary Hypertension of the Newborn.
MedLine Citation:
PMID:  23143352     Owner:  NLM     Status:  Publisher    
Transposition of the great arteries (TGA) in the newborn combined with persistent pulmonary hypertension was reported previously to occur in 3-12 % of full-term neonates with TGA. Right-to-left shunting at the ductal level causes severe hypoxemia despite prostaglandin infusion and balloon atrial septostomy. Although the introduction of inhaled nitric oxide (iNO) has improved the prognosis, this condition still is associated with high preoperative mortality. This report describes the case of a newborn with TGA and persistent pulmonary hypertension, which was managed successfully with oral sildenafil, iNO, and inhaled iloprost during life-threatening acute pulmonary hypertension, thus preventing the use of extracorporeal membrane oxygenation.
Alejandro Avila-Alvarez; Maria Carmen Bravo-Laguna; Lucía Deiros Bronte; Maria Jesus Del Cerro
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-11
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, Department of Neonatology, Hospital Infantil Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain,
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