Document Detail

Inhalational nickel carbonyl poisoning in waste processing workers.
MedLine Citation:
PMID:  16002966     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nickel carbonyl is formed when carbon monoxide comes into contact with active nickel. The inhaled nickel carbonyl is rapidly absorbed and distributed mainly to the lungs, brain, adrenal glands, and kidneys. In severe cases, acute nickel carbonyl exposure has been reported to cause death. DESIGN: Descriptive study. PATIENTS: Seven young men presented with fever, chills, substernal pleuritic chest pain, and exertional dyspnea. Extensive microbiological and toxicological investigations (including blood, urine, and bronchial specimens) for known pathogens and occupational toxins were performed. The clinical course and radiologic findings of each patient, including autopsy findings of three patients who died, were described. RESULTS: Four patients received treatment in the ICU. Elevated urinary nickel concentration was detected in all patients. Results of extensive microbiological investigations were unremarkable. No patients received chelating agents. Pulmonary consolidation, edema, hemorrhage, and fibrosis were observed at autopsy in patients who died. An out-of-date chemical used during neutralization of nickel waste was implicated as the source of nickel carbonyl poisoning. CONCLUSIONS: High mortality was reported in patients who presented subacutely following nickel carbonyl exposure. Further studies should be performed to clarify the role of chelation therapy in the subacute phases following nickel carbonyl exposure.
Raymond C S Seet; Azman Johan; Cuthbert E S Teo; Siok Lin Gan; Kang Hoe Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  128     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-08     Completed Date:  2005-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  AIM; IM    
Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
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MeSH Terms
Air Pollutants, Occupational / poisoning*
Fatal Outcome
Occupational Diseases / chemically induced*,  diagnosis*,  mortality
Occupational Exposure*
Organometallic Compounds / poisoning*
Singapore / epidemiology
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Organometallic Compounds; 13463-39-3/nickel carbonyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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