Document Detail


Inhalational anesthesia: basic pharmacology, end organ effects, and applications in the treatment of status asthmaticus.
MedLine Citation:
PMID:  19854718     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The potent inhalational anesthetic agents are used on a daily basis to provide intraoperative anesthesia. Given their beneficial effects on airway tone and reactivity, they also have a role in the treatment of status asthmaticus that is refractory to standard therapy. Although generally not of clinical significance, these agents can affect various physiological functions. The potent inhalational anesthetic agents decrease mean arterial pressure and myocardial contractility. The decrease in mean arterial pressure reduces renal and hepatic blood flow. Secondary effects on end-organ function may result from the metabolism of these agents and the release of inorganic fluoride. The following article reviews the history of inhalational anesthesia, the physical structure of the inhalational anesthetic agents, their end-organ effects, reports of their use for the treatment of refractory status asthmaticus in the intensive care unit (ICU) patient, and special considerations for their administration in this setting including equipment for their delivery, scavenging, and monitoring.
Authors:
Joseph D Tobias
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Publication Detail:
Type:  Journal Article     Date:  2009-10-22
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  24     ISSN:  1525-1489     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-71     Citation Subset:  IM    
Affiliation:
Departments of Anesthesiology and Pediatrics, University of Missouri, Columbia, Missouri 01199, USA. Tobiasj@health.missouri.edu
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